Three-Decade Evaluation of Cerebrospinal Fluid Pressure in Open-Angle Glaucoma at a Tertiary Care Center.
Three-Decade Evaluation of Cerebrospinal Fluid Pressure in Open-Angle Glaucoma at a Tertiary Care Center.
复制标题
第三纪念中心的开角青光眼中脑脊液压力的三个十年评估。
DOI：
10.1155/2020/7487329
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发表时间：
2020
影响因子：
1.9
通讯作者：
Fautsch MP
中科院分区：
文献类型：
--
作者：
Knier CG;Fleischman D;Hodge DO;Berdahl JP;Fautsch MP
眼压升高是原发性开角型青光眼最常见的危险因素。然而，眼压本身并不能完全描述正常眼压性青光眼或原发性开角型青光眼患者的发病机制。跨层压差(TLPD)理论认为，当眼压高于正常和/或CSFP低于正常时，眼压和脑脊液压力差在视神经水平上产生的压力梯度可导致拔罐和青光眼。到目前为止的研究结果大体上支持TLPD理论；然而，不同的方法、人群和样本量使得比较结果变得困难。为了进一步评估低CSFP与开角型青光眼之间是否存在关联，我们分析了30年来评估96,543个腰椎穿刺点的临床数据。调整年龄和性别后，开角型青光眼患者的CSFP显著低于随机选择的正常对照组(9.9 ± 3 mm·Hg(n = 86)比12.1 ± 3.6 mm·Hg(n = 114)，p<；0.001)。这项回顾性研究为开角型青光眼与低CSFP之间的关联提供了强有力的证据。
Elevated intraocular pressure (IOP) is the most prevalent risk factor for primary open-angle glaucoma. However, IOP alone does not fully describe a mechanical basis for disease in patients with normal tension glaucoma or primary open-angle glaucoma. The translaminar pressure difference (TLPD) theory proposes that the pressure gradient generated by the difference of IOP and cerebrospinal fluid pressure (CSFp) acting at the level of the optic nerve can lead to cupping and glaucoma when IOP is higher than normal and/or CSFp is lower than normal. The study results to date have generally supported the TLPD theory; however, varying methods, populations, and sample sizes make it difficult to compare results. To further assess whether there is an association between low CSFp and open-angle glaucoma, 30 years of clinical data that assess 96,543 lumbar punctures were analyzed. Patients with open-angle glaucoma showed a significantly lower CSFp than randomly selected normal control patients (9.9 ± 3 mm·Hg (n = 86) versus 12.1 ± 3.6 mm·Hg (n = 114), p < 0.001) following adjustment for age and sex. This retrospective study provides strong evidence for an association between open-angle glaucoma and low CSFp.
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影响因子：
4.4
作者：
Berdahl JP;Fautsch MP;Stinnett SS;Allingham RR
通讯作者：
Allingham RR
DOI：
10.1001/jama.2014.3192
发表时间：
2014-05-14
期刊：
JAMA
影响因子：
--
作者：
Weinreb RN;Aung T;Medeiros FA
通讯作者：
Medeiros FA
影响因子：
3.9
作者：
Pircher, A.;Montali, M.;Killer, H. E.
通讯作者：
Killer, H. E.
影响因子：
28.1
作者：
Bai, Wubin;Shin, Jiho;Rogers, John A.
通讯作者：
Rogers, John A.
影响因子：
13.7
作者：
Iwase, A;Suzuki, Y;Kitazawa, Y
通讯作者：
Kitazawa, Y