Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population.
Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population.
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牙周炎患者患某些癌症的潜在风险：大规模人群的补充荟萃分析
DOI：
10.7150/ijms.46812
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发表时间：
2020
影响因子：
3.6
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Ma H;Zheng J;Li X
背景资料：一些研究报道了牙周炎与食管癌、前列腺癌、肾癌、血液恶性肿瘤和皮肤黑色素瘤之间的生物学联系。本荟萃分析旨在评估牙周炎与上述五种癌症之间的关系。方法：检索关于牙周炎与上述五种癌症之间关系的合格研究。使用Stata 12.0进行统计分析。结果：纳入10篇文章（大多数癌症的样本超过10万例）。具有统计学意义的是，牙周炎患者患食管癌的风险可能增加（HR = 1.79，95% CI：1.15-2.79），前列腺癌（HR = 1.20，95% CI：1.09-1.31），恶性血液病（HR = 1.19，95% CI：1.09-1.29），皮肤黑色素瘤（HR = 1.21，95% CI：1.03-1.42）。然而，牙周炎与肾癌易感性之间的相关性缺乏证据（HR=1.30，95%CI：0.96-1.76）。结论：本荟萃分析揭示了牙周炎与食管癌、前列腺癌、血液恶性肿瘤和皮肤黑色素瘤之间的潜在联系。但是，仍需要大样本量和多变量调整的多中心研究来支持这一结论。
Background: Some studies have reported biological linkages between periodontitis and esophageal cancer, prostate cancer, kidney cancer, hematological malignancy, and melanoma of the skin. This meta-analysis aimed to assess the relationship between periodontitis and the aforementioned five cancers. Methods: Eligible studies on the association between periodontitis and the aforementioned five kinds of cancers were retrieved. The statistical analysis was conducted using Stata 12.0. Results: Ten articles (more than 100,000 samples for most cancers) were included. With statistical significance, participants with periodontitis might have enhanced risks of esophageal cancer (HR = 1.79, 95% CI: 1.15-2.79), prostate cancer (HR = 1.20, 95% CI: 1.09-1.31), hematological malignancy (HR = 1.19, 95% CI: 1.09-1.29), and melanoma of skin (HR = 1.21, 95% CI: 1.03-1.42), compared with those without periodontitis. However, the evidence regarding the correlation between periodontitis and the susceptibility to kidney cancer was lacking (HR=1.30, 95% CI: 0.96-1.76). Conclusions: The present meta-analysis revealed a potential link between periodontitis and esophageal cancer, prostate cancer, hematological malignancy, and melanoma of the skin. However, multi-center studies with large sample sizes and multivariable adjustments are still needed to support the conclusion.
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DOI：
10.1007/s10552-015-0699-9
发表时间：
2016-02
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Mai X;LaMonte MJ;Hovey KM;Freudenheim JL;Andrews CA;Genco RJ;Wactawski-Wende J
通讯作者：
Wactawski-Wende J
影响因子：
3.7
作者：
Gao S;Li S;Ma Z;Liang S;Shan T;Zhang M;Zhu X;Zhang P;Liu G;Zhou F;Yuan X;Jia R;Potempa J;Scott DA;Lamont RJ;Wang H;Feng X
通讯作者：
Feng X
影响因子：
4.3
作者：
Joshi, Nishant;Bissada, Nabil F.;Skillicorn, Robert
通讯作者：
Skillicorn, Robert
影响因子：
2.3
作者：
Guven, Deniz Can;Dizdar, Omer;Hayran, Mutlu
通讯作者：
Hayran, Mutlu
影响因子：
3.7
作者：
Corbella S;Veronesi P;Galimberti V;Weinstein R;Del Fabbro M;Francetti L
通讯作者：
Francetti L