Anatomical correlates of cognitive functions in early Parkinson's disease patients.
Anatomical correlates of cognitive functions in early Parkinson's disease patients.
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DOI：
10.1371/journal.pone.0064222
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Antonini A
中科院分区：
文献类型：
--
作者：
Biundo R;Calabrese M;Weis L;Facchini S;Ricchieri G;Gallo P;Antonini A
认知障碍可能发生在帕金森病(PD)的早期，但与认知功能障碍相关的皮质受累程度需要进一步研究。本研究的目的是确定早期帕金森病患者皮质厚度改变的解剖模式及其与认知功能障碍的关系。我们招募了29名帕金森病患者和21名健康对照。所有PD患者都进行了广泛的神经心理检查，其中14例被诊断为轻度认知功能障碍(PD-MCI)。应用基于表面的皮质厚度分析方法，与对照组比较，研究早期PD患者皮质和皮质下改变的地形图分布，并评估PD-MCI患者的认知与局部皮质改变之间的关系。总体而言，与对照组相比，帕金森病患者表现为局灶性皮质(枕顶区、眶-额区和嗅区)和皮质下变薄。PD-MCI显示右侧顶额区和左侧颞枕区存在广泛的认知缺陷和相关的显着区域增厚。我们的结果证实了灰质厚度在PD相对早期阶段的存在，并支持了先前的研究，表明新皮质和皮质下区域变薄和萎缩。PD-MCI的相对皮质增厚可能表现为代偿性神经可塑性。大脑储备机制可能首先在帕金森病的初始阶段调节认知能力下降。
Cognitive deficits may occur early in Parkinson's disease (PD) but the extent of cortical involvement associated with cognitive dysfunction needs additional investigations. The aim of our study is to identify the anatomical pattern of cortical thickness alterations in patients with early stage PD and its relationship with cognitive disability. We recruited 29 PD patients and 21 healthy controls. All PD patients performed an extensive neuropsychological examination and 14 were diagnosed with mild cognitive impairment (PD-MCI). Surface-based cortical thickness analysis was applied to investigate the topographical distribution of cortical and subcortical alterations in early PD compared with controls and to assess the relationship between cognition and regional cortical changes in PD-MCI. Overall PD patients showed focal cortical (occipital-parietal areas, orbito-frontal and olfactory areas) and subcortical thinning when compared with controls. PD-MCI showed a wide spectrum of cognitive deficits and related significant regional thickening in the right parietal-frontal as well as in the left temporal-occipital areas. Our results confirm the presence of changes in grey matter thickness at relatively early PD stage and support previous studies showing thinning and atrophy in the neocortex and subcortical regions. Relative cortical thickening in PD-MCI may instead express compensatory neuroplasticity. Brain reserve mechanisms might first modulate cognitive decline during the initial stages of PD.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
5.7
作者：
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通讯作者：
Fischl, Bruce
影响因子：
3.3
作者：
Appollonio, I;Leone, M;Nichelli, P
通讯作者：
Nichelli, P
DOI：
10.1017/s1355617706061078
发表时间：
2006-11-01
影响因子：
2.6
作者：
Baldo, Juliana V.;Schwartz, Sophie;Dronkers, Nina F.
通讯作者：
Dronkers, Nina F.