SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus.
SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus.
复制标题
DOI：
10.3389/fnins.2017.00637
复制
发表时间：
2017
影响因子：
4.3
通讯作者：
Fregni F
中科院分区：
文献类型：
--
作者：
Pinto CB;Saleh Velez FG;Lopes F;de Toledo Piza PV;Dipietro L;Wang QM;Mazwi NL;Camargo EC;Black-Schaffer R;Fregni F
Selective serotonin reuptake inhibitors (SSRIs) are currently widely used in the field of the neuromodulation not only because of their anti-depressive effects but also due to their ability to promote plasticity and enhance motor recovery in patients with stroke. Recent studies showed that fluoxetine promotes motor recovery after stroke through its effects on the serotonergic system enhancing motor outputs and facilitating long term potentiation, key factors in motor neural plasticity. However, little is known in regards of the exact mechanisms underlying these effects and several aspects of it remain poorly understood. In this manuscript, we discuss evidence supporting the hypothesis that SSRIs, and in particular fluoxetine, modulate inhibitory pathways, and that this modulation enhances reorganization and reestablishment of excitatory-inhibitory control; these effects play a key role in learning induced plasticity in neural circuits involved in the promotion of motor recovery after stroke. This discussion aims to provide important insights and rationale for the development of novel strategies for stroke motor rehabilitation.
登录
查看更多内容
影响因子：
8.3
作者：
Di Lazzaro, Vincenzo;Profice, Paolo;Dileone, Michele
通讯作者：
Dileone, Michele
影响因子：
3.4
作者：
Dong, Lu;Li, Baoman;Peng, Liang
通讯作者：
Peng, Liang
影响因子：
--
作者：
Carmichael, S. Thomas
通讯作者：
Carmichael, S. Thomas
影响因子：
13.9
作者：
Feldman DE
通讯作者：
Feldman DE
影响因子：
11.2
作者：
Bütefisch, CM;Davis, BC;Cohen, LG
通讯作者：
Cohen, LG