Regulatory role of the RstB-RstA system in adhesion, biofilm production, motility, and hemolysis.
Regulatory role of the RstB-RstA system in adhesion, biofilm production, motility, and hemolysis.
复制标题
RstB-RstA 系统在粘附、生物膜产生、运动和溶血中的调节作用
DOI:
10.1002/mbo3.599
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发表时间:
2018-10
期刊:
影响因子:
3.4
通讯作者:
Yan Q
中科院分区:
文献类型:
--
作者:
Huang L;Xu W;Su Y;Zhao L;Yan Q
For infection, initial invasion of the host is of great importance, with adhesion playing a critical role. We previously demonstrated rstA and rstB are remarkably downregulated in Vibrio alginolyticus cultured under heavy metal and acidic stresses, with impaired adhesion, suggesting that rstA and rstB might be involved in adhesion regulation. The present study showed that rstA and rstB silencing resulted in impaired adhesion, biofilm production, motility, hemolysis, and virulence. Meanwhile, changes of temperature, starvation, and pH remarkably affected rstA and rstB expression. These findings indicated that (1) rstA and rstB are critical regulators of adhesion in V. alginolyticus; (2) rstA and rstB have remarkable effects on biofilm production, motility, hemolysis, and virulence in V. alginolyticus; (3) rstA and rstB modulate adhesion in response to environmental changes of temperature, pH, and starvation.
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