Regulatory role of the RstB-RstA system in adhesion, biofilm production, motility, and hemolysis.

Regulatory role of the RstB-RstA system in adhesion, biofilm production, motility, and hemolysis.
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RstB-RstA 系统在粘附、生物膜产生、运动和溶血中的调节作用

DOI:
10.1002/mbo3.599
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发表时间:
2018-10
期刊:
影响因子:
3.4
通讯作者:
Yan Q
Yan Q
中科院分区:
生物学3区
文献类型:
--
作者:
Huang L;Xu W;Su Y;Zhao L;Yan Q

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对于感染,宿主的初始侵袭是非常重要的,其中粘附起着关键作用。我们以前证明rstA和rstB显着下调溶藻弧菌培养下重金属和酸性应力,受损的粘附,这表明rstA和rstB可能参与粘附调节。目前的研究表明,rstA和rstB沉默导致受损的粘附,生物膜的生产,运动,溶血和毒力。同时,温度、饥饿和pH的变化显著影响rstA和rstB的表达。这些结果表明:(1)rstA和rstB是溶藻弧菌粘附的关键调节因子;(2)rstA和rstB对溶藻弧菌生物膜的产生、运动性、溶血性和毒力有显著影响;(3)rstA和rstB调节粘附以响应温度、pH和饥饿等环境变化。
For infection, initial invasion of the host is of great importance, with adhesion playing a critical role. We previously demonstrated rstA and rstB are remarkably downregulated in Vibrio alginolyticus cultured under heavy metal and acidic stresses, with impaired adhesion, suggesting that rstA and rstB might be involved in adhesion regulation. The present study showed that rstA and rstB silencing resulted in impaired adhesion, biofilm production, motility, hemolysis, and virulence. Meanwhile, changes of temperature, starvation, and pH remarkably affected rstA and rstB expression. These findings indicated that (1) rstA and rstB are critical regulators of adhesion in V. alginolyticus; (2) rstA and rstB have remarkable effects on biofilm production, motility, hemolysis, and virulence in V. alginolyticus; (3) rstA and rstB modulate adhesion in response to environmental changes of temperature, pH, and starvation.
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