The influence of nonautonomous P elements on hybrid dysgenesis in Drosophila melanogaster.

The influence of nonautonomous P elements on hybrid dysgenesis in Drosophila melanogaster.
复制标题

非自主P元件对果蝇杂交发育不全的影响。

DOI:
10.1093/genetics/117.4.671
复制
发表时间:
1987
期刊:
影响因子:
3.3
通讯作者:
Zunt,JR
Zunt,JR
中科院分区:
生物学2区
文献类型:
--
作者:
Simmons,MJ;Raymond,JD;Boedigheimer,MJ;Zunt,JR

文献摘要

参考文献

被引文献

相似文献

研究了 M' 品系 Muller-5 Birmingham 的近交系影响 P-M 杂种发育不全的能力。该菌株拥有 57 个 P 元件,所有这些元件在 P 转座酶的产生方面均明显存在缺陷。与转座酶产生元件结合,这些非自主元件可以增强或减少杂种发育不全的发生率,具体取决于所研究的性状。具有一条或多条带有这些元件的父系衍生染色体的基因缺陷果蝇部分地抑制P元件插入突变snw的不稳定性;然而,此类果蝇的另一种基因缺陷性状(GD 不育性)的出现频率较高,并且还表现出扭曲的分离率。提出了一种解释,其中所有这些现象都统一为种系中 P 元素激活动力学的表现。 Muller-5 Birmingham 雌性的后代表现出对 snwin 稳定性和 GD 不育性的部分抑制。这种压抑似乎涉及一个可以通过母系传播至少两代人的因素。因此,这种抑制模式符合 P 细胞型的遗传模式,这种情况导致某些菌株中 P 元件活性几乎完全受到抑制。讨论了这种抑制可能由伯明翰 Muller-5 的非自治元素引起的模型。
An inbred line of the M' strain Muller-5 Birmingham was studied for its abilities to affect P-M hybrid dysgenesis. This strain possesses 57Pelements, all of which are apparently defective in the production of the P transposase. In combination with transposase-producing elements, these nonautonomous elements can enhance or diminish the incidence of hybrid dysgenesis, depending on the trait that is studied. Dysgenic flies that have one or more paternally-derived chromosomes with these elements partially repress the instability of thePelement insertion mutation, snw; however, such flies have elevated frequencies of another dysgenic trait, GD sterility, and also show distorted segregation ratios. An explanation is presented in which all of these phenomena are unified as manifestations of the kinetics ofPelement activation in the germ line. The progeny of Muller-5 Birmingham females exhibit partial repression of both snwinstability and GD sterility. This repression appears to involve a factor that can be transmitted maternally through at least two generations. This mode of repression therefore conforms to the pattern of inheritance of the P cytotype, the condition that brings about nearly total repression ofPelement activity in some strains. Models in which this repression could arise from the nonautonomousPelements of Muller-5 Birmingham are discussed.
DOI: 10.1093/genetics/115.4.711
发表时间: 1987
期刊: Genetics
影响因子: 3.3
作者:
Daniels,SB;Clark,SH;Kidwell,MG;Chovnick,A
通讯作者: Chovnick,A
DOI: 10.1016/0092-8674(82)90463-9
发表时间: 1982-01-01
期刊: CELL
影响因子: 64.5
作者:
BINGHAM, PM;KIDWELL, MG;RUBIN, GM
通讯作者: RUBIN, GM
果蝇的杂交发育不全和随机损失假说。
DOI: 10.1101/sqb.1981.045.01.072
发表时间: 1981
期刊: Cold Spring Harbor symposia on quantitative biology
影响因子: --
作者:
W. Engels
通讯作者: W. Engels
当涉及减数分裂前事件时突变率的估计。
DOI: 10.1002/em.2860010110
发表时间: 1979
期刊: Environmental mutagenesis
影响因子: --
作者:
W. Engels
通讯作者: W. Engels