Regulatory mechanism of HIF-1α and its role in liver diseases: a narrative review.
Regulatory mechanism of HIF-1α and its role in liver diseases: a narrative review.
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DOI：
10.21037/atm-21-4222
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发表时间：
2022-01
影响因子：
--
通讯作者：
Zhu H
中科院分区：
文献类型：
--
作者：
Chu Q;Gu X;Zheng Q;Zhu H
综述缺氧诱导因子-1 α（hypoxia-inducible factor-1 alpha，HIF-1α）的结构、调控机制及靶基因，全面阐述其在各种慢性肝病中的作用，为各种肝病的治疗提供新的视角。肝病，特别是慢性肝病，是一个长期存在的公共卫生问题;由于终末期肝硬化和肝癌的死亡率在世界范围内很高，并继续增长。此外，大多数肝脏疾病缺乏有效的靶向治疗，如脂肪肝，酒精性肝病（ALD）和晚期肝癌，药物治疗方法极其有限。由于肝脏是一个高需氧器官，氧供应不足会诱发一系列疾病，而HIF蛋白在这些过程中起着重要作用。广泛检索有关HIF-1α及其对各种肝病作用的文献，分析靶向HIF-1α治疗各种慢性肝病的可行性及面临的挑战。HIF-1α广泛参与ALD、非酒精性脂肪性肝病（NAFLD）、对乙酰氨基酚（APAP）诱导的肝损伤（AILI）、病毒性肝炎、肝细胞癌（HCC）等肝脏疾病的发生、发展和预后。HIF-1α参与复杂的信号通路，在许多肝脏疾病中其表达受到调节。提示以HIF-1α为靶点治疗肝脏疾病的可行性和临床意义。
To summarize the structure, regulatory mechanism, and target genes of hypoxia-inducible factor-1 alpha (HIF-1α) and to comprehensively expound its role in various chronic liver diseases, thus providing a new perspective on the treatment of various liver diseases. Liver disease, especially chronic liver disease, is a long-standing public health problem; the mortality rate due to end-stage cirrhosis and liver cancer is high worldwide and continues to grow. Moreover, there is a lack of effective targeted therapy for most liver diseases, such as fatty liver, alcoholic liver disease (ALD), and advanced liver cancer, for which drug treatment approaches are extremely limited. As the liver is a highly aerobic organ, an insufficient oxygen supply can induce a series of diseases, and HIF proteins play an important role in these processes. Literature on HIF-1α and its effects on various liver diseases were extensively searched, and the feasibility and challenges of targeting HIF-1α to treat various chronic liver diseases were analyzed. HIF-1α is widely involved in the occurrence, development, and prognosis of ALD, nonalcoholic fatty liver disease (NAFLD), acetaminophen (APAP)-induced liver injury (AILI), viral hepatitis, hepatocellular carcinoma (HCC), and other liver diseases. HIF-1α participates in complex signaling pathways, and its expression is regulated in many liver diseases. These results suggest the feasibility and clinical significance of targeting HIF-1α to treat liver diseases.
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影响因子：
3.7
作者：
Guo, Xiaoqiang;Wang, Yuejia;Duan, Xianglin
通讯作者：
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影响因子：
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作者：
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影响因子：
8.3
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通讯作者：
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影响因子：
29.4
作者：
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--
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影响因子：
10.3
作者：
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