Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs.
Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs.
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DOI：
10.2174/156652411797536679
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发表时间：
2011-11
影响因子：
2.5
通讯作者：
Wu E
中科院分区：
文献类型：
--
作者：
Shan T;Ma Q;Guo K;Liu J;Li W;Wang F;Wu E
尽管经过数十年的研究，恶性肿瘤的治疗和管理仍然是公共卫生面临的一个巨大挑战。癌症治疗的新策略正在开发中，其中最有希望的治疗策略之一涉及化学预防剂的应用。寻找新的和有效的癌症化学预防剂已经导致鉴定各种天然存在的化合物。山竹（Garcinia mangostana Linn）的果皮、整个果实、心材和叶子中的山酮。（GML），已知具有广泛的药理学特性，包括抗氧化，抗肿瘤，抗过敏，抗炎，抗菌，抗真菌和抗病毒活性。在癌变的不同阶段（起始、促进和进展），已经证明了山酮类药物潜在的化学预防和化学治疗活性，并且已知它可以控制细胞分裂和生长、细胞凋亡、炎症和转移。来自大量体外和体内研究的多条证据证实，克山酮通过调节各种靶点和信号转导途径抑制多种人类肿瘤细胞类型的增殖。在这里，我们提供了一个简明而全面的临床前数据回顾，并评估观察到的抗肿瘤作用，支持其作为抗癌药物的显着潜力。
Despite decades of research, the treatment and management of malignant tumors still remain a formidable challenge for public health. New strategies for cancer treatment are being developed, and one of the most promising treatment strategies involves the application of chemopreventive agents. The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds. Xanthones, from the pericarp, whole fruit, heartwood, and leaf of mangosteen (Garcinia mangostana Linn., GML), are known to possess a wide spectrum of pharmacologic properties, including anti-oxidant, anti-tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities. The potential chemopreventive and chemotherapeutic activities of xanthones have been demonstrated in different stages of carcinogenesis (initiation, promotion, and progression) and are known to control cell division and growth, apoptosis, inflammation, and metastasis. Multiple lines of evidence from numerous in vitro and in vivo studies have confirmed that xanthones inhibit proliferation of a wide range of human tumor cell types by modulating various targets and signaling transduction pathways. Here we provide a concise and comprehensive review of preclinical data and assess the observed anticancer effects of xanthones, supporting its remarkable potential as an anticancer agent.
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影响因子：
5.1
作者：
Han, Ah-Reum;Kim, Jeong-Ah;Lantvit, Daniel D.;Leonardus, B. S. Kardono;Riswan, Soedarsono;Chai, Heebyung;de Blanco, Esperanza J. Carcache;Farnsworth, Norman R.;Swanson, Steven M.;Kinghorn, A. Douglas
通讯作者：
Kinghorn, A. Douglas
影响因子：
4
作者：
Collins, I;Garrett, MD
通讯作者：
Garrett, MD
影响因子：
9.7
作者：
Abdi, S;Ali, A
通讯作者：
Ali, A
影响因子：
5.4
作者：
Chomnawang, MT;Surassmo, S;Gritsanapan, W
通讯作者：
Gritsanapan, W
影响因子：
3
作者：
Gali-Muhtasib, Hala;Bakkar, Nadine
通讯作者：
Bakkar, Nadine