Walking Speed, Cognitive Function, and Dementia Risk in the English Longitudinal Study of Ageing.
Walking Speed, Cognitive Function, and Dementia Risk in the English Longitudinal Study of Ageing.
复制标题
在英国衰老纵向研究中，步行速度，认知功能和痴呆症风险。
DOI：
10.1111/jgs.15312
复制
发表时间：
2018-09
影响因子：
6.3
通讯作者：
Steptoe A
中科院分区：
文献类型：
--
作者：
Hackett RA;Davies-Kershaw H;Cadar D;Orrell M;Steptoe A
确定步行速度、认知功能之间的关系，以及这些指标的变化与痴呆症风险之间的相互作用。纵向观察性研究。英国关于老龄化的纵向研究。60岁及以上的个人(N=3932)。在英国老龄化纵向研究的第1波(2002-03)和第2波(2004-05)中对步行速度和认知能力进行了评估。从第三波(2006-07)到第七波(2014-15)评估了新的痴呆症病例。用COX比例风险回归法对这些相关性进行建模。基线步行速度较快的参与者患痴呆症的风险较低(危险比(HR)=0.36，95%可信区间(CI)=0.22-0.60)。步速从第一波下降到第二波的人患痴呆症的风险更大(HR=1.23，95%CI=1.03-1.47)。基线认知较好的参与者(HR=0.42，95%CI=0.34~0.54)患痴呆症的风险较低。第1~2波认知功能减退程度越大，患痴呆症的风险越大(HR=1.78，95%CI=1.53~2.06)。步行速度的改变和认知的改变对痴呆风险没有交互作用(HR=1.01，95%CI=0.88-1.17)。在这个居住在社区的英国成年人样本中，那些走路速度较慢、随着时间的推移速度下降较大的人患痴呆症的风险更大，而不受认知变化的影响。需要进一步的研究来了解可能推动这些联系的机制。参见https://doi.org/https://doi.org/10.1111/jgs.15368.的相关社论
To determine the relationships between walking speed, cognitive function, and the interaction between changes in these measures and dementia risk. Longitudinal observational study. English Longitudinal Study of Ageing. Individuals aged 60 and older (N=3,932). Walking speed and cognition were assessed at Waves 1 (2002–03) and 2 (2004–05) of the English Longitudinal Study of Ageing. New dementia cases were assessed from Wave 3 (2006–07) to Wave 7 (2014–15). The associations were modelled using Cox proportional hazards regression. Participants with faster baseline walking speeds were at lower risk of developing dementia (hazard ratio (HR)=0.36, 95% confidence interval (CI)=0.22–0.60). Those with a greater decline in walking speed from Wave 1 to 2 were at greater risk of developing dementia (HR=1.23, 95% CI=1.03–1.47). Participants with better baseline cognition (HR=0.42, 95% CI=0.34–0.54) were at lower risk of developing dementia. Those with a greater decline in cognition from Wave 1 to 2 were at greater risk of developing dementia (HR=1.78, 95% CI=1.53–2.06). Change in walking speed and change in cognition did not have an interactive effect on dementia risk (HR=1.01, 95% CI=0.88–1.17). In this community‐dwelling sample of English adults, those with slower walking speeds and a greater decline in speed over time were at greater risk of developing dementia independent of changes in cognition. Further research is required to understand the mechanisms that may drive these associations. See related editorial by https://doi.org/https://doi.org/10.1111/jgs.15368.
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影响因子：
3.7
作者：
Mahlknecht P;Kiechl S;Bloem BR;Willeit J;Scherfler C;Gasperi A;Rungger G;Poewe W;Seppi K
通讯作者：
Seppi K
影响因子：
6.9
作者：
JORM, AF
通讯作者：
JORM, AF
影响因子：
5.5
作者：
Clouston SA;Brewster P;Kuh D;Richards M;Cooper R;Hardy R;Rubin MS;Hofer SM
通讯作者：
Hofer SM
影响因子：
5.1
作者：
Allali G;Annweiler C;Blumen HM;Callisaya ML;De Cock AM;Kressig RW;Srikanth V;Steinmetz JP;Verghese J;Beauchet O
通讯作者：
Beauchet O
DOI：
10.3233/jad-161160
发表时间：
2017
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Khondoker M;Rafnsson SB;Morris S;Orrell M;Steptoe A
通讯作者：
Steptoe A