Prevention and Treatment of Side Effects of Immunotherapy for Bladder Cancer.

Prevention and Treatment of Side Effects of Immunotherapy for Bladder Cancer.
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膀胱癌免疫治疗副作用的预防和治疗

DOI:
10.3389/fonc.2022.879391
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发表时间:
2022
影响因子:
4.7
通讯作者:
--
中科院分区:
医学3区
文献类型:
--
作者:

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膀胱癌是泌尿生殖系统最重要的肿瘤之一,具有较高的发病率和死亡率。多年来,各种抗肿瘤治疗方法相继问世,免疫治疗是其中最有效的方法之一。免疫疗法旨在激活人体免疫系统以杀死癌细胞。现已确定,免疫治疗药物可根据作用部位分为“非靶向”药物和“靶向”药物。据报道,免疫疗法对BC有效。即使它可以攻击癌细胞,它也可以导致免疫系统攻击健康细胞,这种情况可能在治疗过程中的任何时候发生,有时甚至在免疫治疗停止后发生。重要的是,不同类型的免疫疗法会导致不同的副作用。副作用可能会表现为体征或症状。预防和治疗免疫治疗引起的副作用是癌症患者管理的重要内容。
Bladder cancer (BC) is one of the most important tumors of the genitourinary system, associated with high morbidity and mortality rates. Over the years, various antitumor treatments have been developed, and immunotherapy is one of the most effective methods. Immunotherapy aims to activate the body’s immune system to kill cancer cells. It has been established that immunotherapy drugs can be classified into “non-targeted” and “targeted” drugs depending on their site of action. Immunotherapy is reportedly effective for BC. Even though it can attack cancer cells, it can also cause the immune system to attack healthy cells, which can occur at any time during treatment and sometimes even after immunotherapy is stopped. Importantly, different types of immunotherapies can cause different side effects. Side effects may manifest themselves as signs or as symptoms. The prevention and treatment of side effects caused by immunotherapy is an important part of cancer patient management.
PD-1和PD-L1检查点信号传导抑制癌症免疫疗法:机制,组合和临床结果。
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