Association between tooth loss and orodigestive cancer mortality in an 80-year-old community-dwelling Japanese population: a 12-year prospective study.
Association between tooth loss and orodigestive cancer mortality in an 80-year-old community-dwelling Japanese population: a 12-year prospective study.
复制标题
DOI：
10.1186/1471-2458-13-814
复制
发表时间：
2013-09-08
影响因子：
4.5
通讯作者：
Shimada N
中科院分区：
文献类型：
--
作者：
Ansai T;Takata Y;Yoshida A;Soh I;Awano S;Hamasaki T;Sogame A;Shimada N
越来越多的证据表明，口腔和胃肠道（orodigestive）癌症与牙周病或牙齿脱落之间可能存在关联。然而，证据仍然相互矛盾。这项研究调查了牙齿脱落是否与口腔消化道癌症死亡有关，牙齿脱落表明口腔健康状况不佳，是口腔感染的潜在来源。这项研究包括了日本福冈县的656名受试者，他们在1998年的基线年龄为80岁。所有受试者进行口腔临床检查，并回答问卷，以确定他们的背景特征。在公共卫生中心的登记册中记录了12年随访期间的死亡原因，并根据世卫组织国际疾病分类进行了分类。采用Kaplan-Meier和考克斯多变量回归分析进行相关性统计分析。在调整潜在混杂因素（包括性别和吸烟状况）后，观察到牙齿脱落（连续变量）与癌症死亡之间存在显著相关性（风险比（HR）：1.03，95%置信区间（CI）：1.00-1.07）。然而，这种关联在完全调整后的模型中变得微不足道。另一方面，牙齿脱落与口腔消化道癌显著相关（HR：1.06，95%CI：1.01-1.13），即使在完全校正的模型中，包括居住地作为社会经济地位的一部分。这项研究提供了第一个证据，在日本人口的前瞻性研究中，牙齿脱落与口腔消化道癌症死亡率增加有关，尽管因果关系尚不清楚。
A growing body of evidence has indicated a possible association between oral and gastrointestinal (orodigestive) cancers and periodontal disease or tooth loss. However, the evidence remains contradictory. This study investigated whether tooth loss, which is indicative of poor oral health and a potential source of oral infections, is associated with death from orodigestive cancer. The study included 656 subjects in Fukuoka prefecture, Japan, who were 80 years old at baseline in 1998. All subjects underwent oral clinical examination and answered a questionnaire to determine their background characteristics. Cause of death over the 12-year follow-up was recorded from the registers at the Public Health Centers and classified according to the WHO International Classification of Diseases. Statistical analysis of associations was performed using Kaplan-Meier and Cox multivariate regression analyses. A significant association was observed between tooth loss (continuous variable) and cancer death (hazard ratio (HR): 1.03, 95% confidence interval (CI): 1.00–1.07), after adjustment for potential confounders, including sex and smoking status. However, that association became insignificant in the fully adjusted model. On the other hand, tooth loss was significantly associated with orodigestive cancer (HR: 1.06, 95% CI: 1.01–1.13), even in the fully adjusted model including place of residence as a part of socioeconomic status. This study provides the first evidence in a prospective study in a Japanese population that tooth loss is associated with increased orodigestive cancer mortality, although the causality remains unclear.
登录
查看更多内容
影响因子：
4.5
作者：
Ansai T;Takata Y;Soh I;Awano S;Yoshida A;Sonoki K;Hamasaki T;Torisu T;Sogame A;Shimada N;Takehara T
通讯作者：
Takehara T
影响因子：
3.8
作者：
Hiraki, Akio;Matsuo, Keitaro;Tajima, Kazuo
通讯作者：
Tajima, Kazuo
影响因子：
2.3
作者：
Abnet, CC;Qiao, YL;Dawsey, SM
通讯作者：
Dawsey, SM
影响因子：
5.7
作者：
Tu, Yu-Kang;Galobardes, Bruna;Gilthorpe, Mark S.
通讯作者：
Gilthorpe, Mark S.
影响因子：
51.1
作者：
Michaud, Dominique S.;Liu, Yan;Joshipura, Kaumudi
通讯作者：
Joshipura, Kaumudi