Adiposity, adult weight gain and mammographic breast density in US Chinese women.
Adiposity, adult weight gain and mammographic breast density in US Chinese women.
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DOI：
10.1002/ijc.25338
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发表时间：
2011-01-15
影响因子：
6.4
通讯作者：
Byrne, Celia
中科院分区：
文献类型：
--
作者：
Tseng, Marilyn;Byrne, Celia
肥胖症与乳房致密组织区域的关联尚不清楚，但暗示了肥胖症可能增加乳腺癌风险的机制。我们在一个绝经前的美国华裔移民女性样本中，研究了体重指数(BMI)、20-29岁年龄段通常的BMI、腰围和成年体重增加与乳房密度的关系。分析包括费城一项纵向乳房密度研究的415名参与者。除了详细的问卷信息外，数据收集还包括人体测量和使用计算机辅助方法评估乳房X光检查的乳房密度。我们使用多元线性回归来量化横截面与致密和非致密组织面积以及在基线时评估的乳房密度百分比之间的关系。在调整后的模型中，BMI和腰围与非致密组织面积显著正相关，与百分比密度负相关。BMI与致密组织面积呈显著正相关。在调整了20-29岁的体重后，成人体重增加与致密组织面积相关。在分层分析中，在BMI<23 kg/m2的女性中，BMI和成人体重增加与致密组织面积显著相关，而在BMI<23 kg/m2的女性中，BMI与非致密组织面积相关。在这个样本中，肥胖和体重增加与致密的乳房组织面积相关，尽管相关关系因肥胖程度不同而不同。考虑到这些发现对绝经前妇女乳腺癌预防的潜在影响，需要在其他人群中进行类似研究并提供纵向数据。引起肥胖程度差异的原因也值得进一步研究。
The association of adiposity with dense tissue area in the breast is unclear but suggests a mechanism by which adiposity might increase breast cancer risk. We examined associations of body mass index (BMI), usual BMI from age 20–29, waist circumference, and adult weight gain with breast density in a sample of premenopausal US Chinese immigrant women. Analyses included 415 participants in a longitudinal breast density study in Philadelphia. In addition to detailed questionnaire information, data collection included measures of anthropometry, and assessment of mammographic breast density using a computer-assisted method. We used multivariate linear regression to quantify cross-sectional associations with dense and non-dense tissue area and percent breast density assessed at baseline. In adjusted models, BMI and waist circumference were significantly positively associated with non-dense tissue area and inversely associated with percent density. BMI was also significantly positively associated with dense tissue area. Adult weight gain was associated with dense tissue area after adjusting for weight from age 20–29. In stratified analyses, BMI and adult weight gain were significantly associated with dense tissue area among women with BMI <23 kg/m2, and BMI was associated with non-dense tissue area among women with BMI >=23 kg/m2. In this sample, adiposity and weight gain were associated with dense breast tissue area, although associations differed by level of adiposity. Given the potential implications of these findings for breast cancer prevention in premenopausal women, comparable studies in other population groups and with longitudinal data are needed. Reasons for the noted differences in associations by level of adiposity also warrant further investigation.
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影响因子：
5.6
作者：
El-Bastawissi, AY;White, E;Taplin, S
通讯作者：
Taplin, S
DOI：
10.3109/13697139809080677
发表时间：
1998-03-01
期刊：
Climacteric : the journal of the International Menopause Society
影响因子：
--
作者：
Dudley, E C;Hopper, J L;Dennerstein, L
通讯作者：
Dennerstein, L
影响因子：
3.8
作者：
Aiello, EJ;Tworoger, SS;McTiernan, A
通讯作者：
McTiernan, A
影响因子：
8.8
作者：
Boyd, NF;Stone, J;Martin, LJ;Jong, R;Fishel, E;Yaffe, M;Hammond, G;Minkin, S
通讯作者：
Minkin, S
DOI：
10.1002/j.1550-8528.1999.tb00404.x
发表时间：
1999-05-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Clasey, JL;Bouchard, C;Weltman, A
通讯作者：
Weltman, A