Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis.
Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis.
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DOI：
10.3390/nu14173576
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发表时间：
2022-08-30
期刊：
影响因子：
5.9
通讯作者：
Ding C
中科院分区：
文献类型：
--
作者：
Zhang Y;Chen T;Luo P;Li S;Zhu J;Xue S;Cao P;Zhu Z;Li J;Wang X;Wluka AE;Cicuttini F;Ruan G;Ding C
背景：骨关节炎（OA）是老年人最常见的关节疾病，目前尚无治愈方法。大量元素对人体健康至关重要，它们与OA的关系尚不清楚。阐明大量元素和OA之间的关系可能有助于膝关节OA的管理。方法：本研究是一项事后分析，使用的数据来自一项为期两年的随机对照试验，纳入392名膝关节OA受试者。饮食中的大量元素，包括钙、镁、钾和磷，是根据基线时的半定量食物频率问卷计算的。在基线和第24个月评估膝关节结构（包括软骨体积、软骨缺损、骨髓病变和积液-滑膜炎体积）、OA症状、生活质量和OA共病状况（包括下肢肌力和抑郁症状）。在基线和第3、6、12和24个月评估西安大略和麦克马斯特大学（WOMAC）指数和抑郁症状。在基线和第6、12和24个月评估生活质量和下肢肌肉力量。所有分析均采用混合效应模型进行。结果如下：膳食中较高的镁和钾与OA症状较少、生活质量较高、下肢肌肉力量较大和抑郁症状较少相关，但与膝关节结构无关。除了膳食磷与下肢肌肉力量增强相关外，膳食钙和磷含量较高与任何OA相关结果无关。结论：在纵向分析中，较高的膳食镁和钾摄入量与膝关节OA患者的OA症状较少、生活质量较高和合并症较轻相关，表明膳食镁和钾可能对OA有有益影响，可用于膝关节OA管理。
Background: Osteoarthritis (OA), the most common joint disease in the elderly, has no cure. Macroelements are vital in human health and their relationships with OA are not clear. Clarifying the relationships between macroelements and OA may assist knee OA management. Methods: This study was a post-hoc analysis using data from a two-year randomized controlled trial among 392 participants with knee OA. Dietary macroelements, including calcium, magnesium, potassium, and phosphorus were computed-based on a semi-quantitative food frequency questionnaire at baseline. Knee joint structures (including cartilage volume, cartilage defect, bone marrow lesions, and effusion-synovitis volume), OA symptoms, quality of life, and OA comorbid conditions (including lower limb muscle strength and depressive symptoms) were assessed at baseline and month 24. Western Ontario and McMaster Universities (WOMAC) Index and depressive symptoms were assessed at baseline and months 3, 6, 12, and 24. Quality of life and lower limb muscle strength were assessed at baseline and months 6, 12, and 24. All analyses were conducted using mixed-effects models. Results: Higher dietary magnesium and potassium were associated with fewer OA symptoms, higher quality of life, greater lower limb muscle strength, and fewer depressive symptoms, but not with knee joint structures. Higher dietary calcium and phosphorus was not associated with any of the OA-related outcomes, except that dietary phosphorus was associated with greater lower limb muscle strength. Conclusions: In the longitudinal analyses, higher dietary magnesium and potassium intake are associated with fewer OA symptoms, higher quality of life, and milder comorbid conditions in patients with knee OA, suggesting dietary magnesium and potassium may have beneficial effects on OA and could be used for knee OA management.
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