Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive dysfunction in children.
Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive dysfunction in children.
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DOI：
10.1007/s11356-014-3627-8
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Sowa A
中科院分区：
文献类型：
--
作者：
Jedrychowski WA;Perera FP;Camann D;Spengler J;Butscher M;Mroz E;Majewska R;Flak E;Jacek R;Sowa A
多环芳烃（Polycyclicaromatic hydrocarbons，PAHs）是化石燃料和其他有机物燃烧产生的广泛的环境污染物。实验动物和人类研究都报告了PAH化合物对胎儿生长和神经发育的有害影响，包括儿童的语言智商。在这里，我们评估了儿童认知功能与产前PAH暴露之间的关联。这项研究是一项正在进行的纵向调查的一部分，调查产前暴露于空气污染对波兰克拉科夫的婴儿和儿童的健康影响。本报告中的受试者包括170名母亲在妊娠早期或中期入组研究的儿童，他们的脐带血进行了PAH-DNA加合物检测，并在7岁时使用韦氏儿童智力量表修订版（WISC-R）进行了评估。先验兴趣的结果是抑郁的言语智商指数（DepVIQ），这是WISC-R表现和言语智商得分之间的差异。通过脐带血PAH-DNA加合物（一种个体剂量计）测量产前PAH暴露，整合妊娠期各种暴露源的暴露。产前PAH暴露对认知功能的估计影响在多变量回归中针对一组潜在混杂因素（儿童性别、产次、母亲教育、母乳喂养实践、环境烟草烟雾（ETS）和产后PAH暴露）进行了调整。与检测不到PAH-DNA加合物的儿童相比，检测到PAH-DNA加合物的儿童中DepVIQ的患病率显著更高（13.7% vs. 4.4%）。二元多变量回归证明，随着脐带血加合物的单位增加，DepVIQ的相对风险增加3倍（相对风险（RR）= 3.0，95%置信区间（CI）1.3-6.8）。出生后PAH暴露也增加了DepVIQ的风险（RR = 1.6，95% CI 1.1-2.5）。长期纯母乳喂养（至少6个月）显示出保护作用（RR = 0.3，95% CI 0.1-0.9）。总之，这些结果提供了进一步的证据表明，多环芳烃对发育中的胎儿大脑有害，其影响贯穿儿童时期，并对儿童的学业成功产生影响。
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants produced by combustion of fossil fuel and other organic materials. Both experimental animal and human studies have reported the harmful impacts of PAH compounds on fetal growth and neurodevelopment, including verbal IQ of children. Here, we have assessed the association between cognitive function of children and prenatal PAH exposures. The study is part of an ongoing, longitudinal investigation of the health effects of prenatal exposure to air pollution on infants and children in Krakow, Poland. The subjects in this report included 170 children whose mothers were enrolled to the study in the first or second trimester of pregnancy whose cord blood were tested for PAH–DNA adducts and who were assessed at age 7 using the Wechsler Intelligence Scale for Children-Revised (WISC-R). The outcome of a priori interest was depressed verbal IQ index (DepVIQ), which is the difference between WISC-R performance and verbal IQ scores. Prenatal PAH exposure was measured by cord blood PAH–DNA adducts, an individual dosimeter, integrating exposure from various sources of exposure over the gestational period. The estimated effect of prenatal PAH exposure on cognitive function was adjusted in multivariable regression for a set of potential confounders (child’s gender, parity, maternal education, breastfeeding practice, environmental tobacco smoke (ETS), and postnatal PAH exposure). The prevalence of DepVIQ was significantly higher in children with detectable PAH–DNA adducts compared to those with undetectable adducts (13.7 vs. 4.4 %,). Binary multivariable regression documented that the relative risk of DepVIQ increased threefold with a ln-unit increase in cord blood adducts (relative risk (RR) = 3.0, 95 % confidence interval (CI) 1.3–6.8). Postnatal PAH exposure also increased the risk of DepVIQ (RR = 1.6, 95 % CI 1.1–2.5). Long-term exclusive breastfeeding (at least 6 months) showed a protective effect (RR = 0.3, 95 % CI 0.1–0.9). In conclusion, these results provide further evidence that PAHs are harmful to the developing fetal brain with effects extending through childhood, with implications for the academic success of the children.
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影响因子：
10.4
作者：
Brown, Rebecca C;Lockwood, Alan H;Sonawane, Babasaheb R
通讯作者：
Sonawane, Babasaheb R
影响因子：
10.4
作者：
Eskenazi B;Castorina R
通讯作者：
Castorina R
影响因子：
7.1
作者：
Crawford, Michael A.
通讯作者：
Crawford, Michael A.
DOI：
10.1080/07315724.2004.10719428
发表时间：
2004-12-01
影响因子：
3.5
作者：
Barker, DJP
通讯作者：
Barker, DJP
影响因子：
3.3
作者：
Archibong, AE;Inyang, F;Nyanda, AM
通讯作者：
Nyanda, AM