Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome.
Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome.
复制标题
DOI：
10.1016/j.mce.2009.02.022
复制
发表时间：
2009-05-25
影响因子：
4.1
通讯作者：
Brandebourg TD
中科院分区：
文献类型：
--
作者：
Ben-Jonathan N;Hugo ER;Brandebourg TD
双酚A（BPA）是最普遍和研究最多的内分泌干扰物之一。经过多年暴露于含有BPA的消费品，大多数受试者的循环BPA水平都很低。除了对生殖系统的作用有据可查外，BPA还对代谢产生各种影响。本文综述了BPA在环境相关剂量下抑制脂联素和刺激炎症性脂肪因子如白细胞介素-6（IL-6）和肿瘤坏死因子α（TNFα）从人体脂肪组织中释放的能力的最新研究结果。人类脂肪组织中几种经典和非经典雌激素受体的表达提高了它们作为BPA作用介质参与的可能性。这些意见的影响，肥胖相关的代谢综合征及其后遗症进行了讨论。
Bisphenol A (BPA) is one of the most prevalent and best studied endocrine disruptors. After years of exposure to consumer products containing BPA, most individuals tested have circulating BPA at the low nanomolar levels. In addition to its well documented actions on the reproductive system, BPA exerts a wide variety of metabolic effects. This review summarizes recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor α (TNFα) from human adipose tissue. Expression of several classical and non-classical estrogen receptors in human adipose tissue raises the possibility of their involvement as mediators of BPA actions. The implications of these observations to the obesity-related metabolic syndrome and its sequalae are discussed.
登录
查看更多内容
影响因子：
4.8
作者：
Fain, JN;Madan, AK;Bahouth, SW
通讯作者：
Bahouth, SW
影响因子：
10.4
作者：
Alonso-Magdalena P;Morimoto S;Ripoll C;Fuentes E;Nadal A
通讯作者：
Nadal A
影响因子：
5.8
作者：
Andersen, Kristian Kjaer;Frystyk, Jan;Flyvbjerg, Allan
通讯作者：
Flyvbjerg, Allan
影响因子：
--
作者：
Heard, DJ;Norby, PL;Vissing, H
通讯作者：
Vissing, H
影响因子：
10.4
作者：
Alonso-Magdalena P;Laribi O;Ropero AB;Fuentes E;Ripoll C;Soria B;Nadal A
通讯作者：
Nadal A