Investigators' perspectives on translating human microbiome research into clinical practice.
Investigators' perspectives on translating human microbiome research into clinical practice.
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DOI：
10.1159/000350308
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发表时间：
2013
影响因子：
1.7
通讯作者：
McGuire AL
中科院分区：
文献类型：
--
作者：
Slashinski MJ;Whitney SN;Achenbaum LS;Keitel WA;McCurdy SA;McGuire AL
Human microbiome research has the potential to transform the practice of medicine, fundamentally shifting the ways in which we think not only about human health, illness, and disease, but also about clinical practice and public health interventions. Drawing from a larger qualitative study on ethical, legal, and social dimensions of human microbiome research, in this article we document perspectives related to the translation of human microbiome research into clinical practice, focusing particularly on implications for health, illness, and disease. We conducted 60 in-depth, semi-structured interviews (2009–2010) with 63 researchers and National Institutes of Health project leaders (“investigators”) involved with human microbiome research. Interviews explored a range of ethical, legal, and social implications of human microbiome research, including investigators’ perspectives on potential strategies for translating findings to clinical practice. Using thematic content analysis, we identified and analyzed emergent themes and patterns. We identified three themes: (1) Investigators’ general perspectives on the clinical utility of human microbiome research, (2) Investigators’ perspectives on antibiotic use, overuse, and misuse, and (3) Investigators’ perspectives concerning future challenges of translating data to clinical practice. The issues discussed by investigators concerning the clinical significance of human microbiome research, including embracing a new paradigm of health and disease, the importance of microbial communities, and clinical utility, will be of critical importance as this research moves forward.
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DOI：
10.1525/jer.2012.7.3.1
发表时间：
2012-07
期刊：
Journal of empirical research on human research ethics : JERHRE
影响因子：
--
作者：
McGuire AL;Achenbaum LS;Whitney SN;Slashinski MJ;Versalovic J;Keitel WA;McCurdy SA
通讯作者：
McCurdy SA
DOI：
10.1126/science.1224203
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
通讯作者：
Relman DA
影响因子：
5.2
作者：
Young VB;Kahn SA;Schmidt TM;Chang EB
通讯作者：
Chang EB
影响因子：
3.7
作者：
Aagaard K;Riehle K;Ma J;Segata N;Mistretta TA;Coarfa C;Raza S;Rosenbaum S;Van den Veyver I;Milosavljevic A;Gevers D;Huttenhower C;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
7
作者：
Nasidze, Ivan;Li, Jing;Stoneking, Mark
通讯作者：
Stoneking, Mark