Visceral fat and arterial stiffness in youth with healthy weight, obesity, and type 2 diabetes.
Visceral fat and arterial stiffness in youth with healthy weight, obesity, and type 2 diabetes.
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DOI：
10.1111/ijpo.12865
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发表时间：
2022-04
影响因子：
3.8
通讯作者：
Kindler JM
中科院分区：
文献类型：
--
作者：
Higgins S;Zemel BS;Khoury PR;Urbina EM;Kindler JM
Visceral fat is associated with increased cardiovascular risk in adults but studies in youth are limited. We assessed associations between visceral fat and arterial stiffness in youth with healthy weight, obesity, and type 2 diabetes, and determined whether relationships were independent of clinical estimates of body fatness. This cross-sectional sample included youth ages 10 to 23 years (67% female, 56% non-black) with healthy weight (BMI=5th to 85th percentile, n=236), obesity (BMI≥95th percentile, n=224), and type 2 diabetes (BMI≥95th percentile, n=145). Visceral fat was assessed via dual-energy X-ray absorptiometry. Carotid-femoral pulse wave velocity (PWV) was assessed via applanation tonometry. Obesity and type 2 diabetes groups were combined for final analyses. Analyses accounted for age, sex, ancestry, and mean arterial pressure. Visceral fat and PWV were greater in youth with obesity vs. healthy weight (p<0.001). In youth with obesity, but not healthy weight, visceral fat was positively associated with PWV (p<0.001), and was predictive of PWV beyond BMI and waist circumference. Visceral fat likely contributes to subclinical cardiovascular complications in youth. Since cardiovascular health tracks from adolescence to adulthood, longitudinal studies in youth with obesity are required to define the role of visceral fat in lifelong cardiovascular disease risk.
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