Cholinesterase research outreach project (CROP): point of care cholinesterase measurement in an Australian agricultural community.
Cholinesterase research outreach project (CROP): point of care cholinesterase measurement in an Australian agricultural community.
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DOI：
10.1186/s12940-018-0374-1
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发表时间：
2018-04-02
期刊：
影响因子：
--
通讯作者：
Brumby S
中科院分区：
文献类型：
--
作者：
Cotton J;Edwards J;Rahman MA;Brumby S
澳大利亚农民经常接触到各种各样的农用化学品，包括除草剂和杀虫剂。有机磷(OP)杀虫剂广泛应用于农业生产、园艺和畜牧业。OP中毒的症状是乙酰胆碱酯酶(AChE)被抑制的结果，AChE存在于人体许多类型的传导组织中，如神经和肌肉、中枢和外周组织、运动和感觉纤维。可在红细胞/红细胞(AChE)和血浆(PChE)中检测胆碱酯酶。这项研究旨在探索将AChE监测整合到对高危人群的常规健康检查中，并在澳大利亚的一个维多利亚时期的农业社区中检查AChE活动和农化使用之间的任何关联。这是一项前瞻性队列研究，比较了农民和非农民在基线、3-4周、6周和9周的四个时间点的AChE水平。研究参与者(N = 55)是来自维多利亚州西南部的居民，年龄在18岁到75岁之间，会说英语，以前没有已知的急性化学事故。共有41个农业(从事农业超过5年)和14个非农业个体的便利样本符合纳入标准。所有参与者都重复了AChE测试，在10周内最多测试三次。所有与会者都很好地接受了AChE监测的一体化。在本研究中，农业参与者和非农业参与者之间的平均AChE活性没有显著差异(单因素方差p >； 0.05)。农场个人使用农用化学品与基线(测量1)或任何随访期的AChE水平之间没有显著差异(p >； 0.05)。但在随访期内，AChE的平均活性显著降低[F(139.539，2.633) = 14.967，p <； 0.001]。在随访3周和6周期间，AchE明显减少(p = 0.015)。在农民使用有机磷农药时，常规的乙酰胆碱酯酶监测可以及早识别长期低水平接触有机磷农药，前提是有对基线乙酰胆碱酯酶的合理估计。这项工作为建议将AChE监测整合到农村卫生诊所的护理点(POC)程序中并量化农场和家庭中的农药暴露和个人防护提供了证据。农民的参与对于成功地将AChE监测整合到澳大利亚的农村卫生诊所至关重要。ACTRN12613001256763。
Australian farmers are routinely exposed to a wide variety of agrichemicals, including herbicides and insecticides. Organophosphate (OP) insecticides are widely used for agricultural production, horticulture and animal husbandry practices. Symptoms of OP toxicity are the results of inhibition of the enzyme acetylcholinesterase (AChE) which is found in many types of conducting tissue in human bodies such as nerve and muscle, central and peripheral tissues, motor and sensory fibres. Cholinesterase can be measured in red blood cells/erythrocytes (AChE) and plasma (PChE). This study aims to explore integration of AChE monitoring into routine health checks for those at risk and also to examine any association between AChE activity and agrichemical use in a Victorian farming community in Australia. This was a prospective cohort study, where farmers and non-famers were compared on the levels of AChE at four time points of baseline, 3–4 weeks, 6-weeks and at 9-weeks. Study participants (N = 55) were residents from South West Victoria, aged between 18 and 75 years, spoke English, and had not had a previous known acute chemical accident. A total of 41 farming (had been farming for more than 5 years) and a convenience sample of 14 non-farming individuals met the inclusion criteria. Testing of AChE was repeated for all participants with a maximum of three times over 10 weeks. The integration of AChE monitoring was very well accepted by all participants. There was no significant difference in average AChE activity between farming and non-farming participants (one-way ANOVA p > 0.05) in this study. There was no significant difference between personal use of agricultural chemicals on farm and the levels of AChE at baseline (measurement 1) or any of the follow up periods (p > 0.05). However, the mean activity of AChE was significantly lower within follow up periods [F (2.633, 139.539) = 14.967, p < 0.001]. There was a significant reduction of AChE between the follow up at 3-weeks and 6-weeks period (p = 0.015). The routine monitoring of AChE may allow for early recognition of chronic low-level exposure to OPs when they are used by farmers, provided a reasonable estimate of baseline AChE is available. This work provides an evidence for recommending the integration of AChE monitoring into point of care (POC) procedures in rural health clinics and quantifying pesticide exposure and personal protection both on the farm and in the home. Farmer engagement is crucial to the successful integration of AChE monitoring into rural health clinics in Australia. ACTRN12613001256763.
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5.8
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