Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer's disease.
Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer's disease.
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DOI：
10.1186/s13578-023-01085-5
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发表时间：
2023-07-28
影响因子：
7.5
通讯作者：
Zhao, Min
中科院分区：
文献类型：
--
作者：
Liu, Qian;Contreras, Adam;Afaq, Muhammad Shan;Yang, Weijian;Hsu, Daniel K.;Russell, Michael;Lyeth, Bruce;Zanto, Theodore P.;Zhao, Min
关键词：
感觉刺激可减少ad特异性病理。然而，交流电流刺激在AD动物模型中的效果尚不清楚，并且先前的研究尚未解决强度依赖性效应。研究了40 Hz正弦交流电刺激（GES）对5xFAD小鼠海马和皮层a β清除和小胶质细胞调节的强度依赖性影响，以及Morris水迷宫动物的行为表现。1小时的硬膜外GES在一个月内显著(1)减少AD大脑中的a β负荷，(2)增加小胶质细胞计数，减小细胞体积，增加Iba1 +细胞的细胞过程长度，以及(3)改善行为表现（学习和记忆）。所有这些效应在施加较高的刺激电流时最为明显。GES在减少AD病理上的疗效和强度依赖性特征为这种有前景的治疗方法的发展提供了指导。
Gamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy of alternating electrical current stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dependent effects. The intensity-dependent effect of gamma electrical stimulation (GES) with a sinusoidal alternating current at 40 Hz on Aβ clearance and microglia modulation were assessed in 5xFAD mouse hippocampus and cortex, as well as the behavioral performance of the animals with the Morris Water Maze. One hour of epidural GES delivered over a month significantly (1) reduced Aβ load in the AD brain, (2) increased microglia cell counts, decreased cell body size, increased length of cellular processes of the Iba1 + cells, and (3) improved behavioral performance (learning & memory). All these effects were most pronounced when a higher stimulation current was applied. The efficacy of GES on the reduction of AD pathology and the intensity-dependent feature provide guidance for the development of this promising therapeutic approach.
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细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
DOI：
10.3791/1262
发表时间：
2009-05-14
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Burke, Mark;Zangenehpour, Shahin;Ptito, Maurice
通讯作者：
Ptito, Maurice
影响因子：
5.7
作者：
Chapelle F;Manciet L;Pereira B;Sontheimer A;Coste J;El Ouadih Y;Cimpeanu R;Gouot D;Lapusta Y;Claise B;Sautou V;Bouattour Y;Marques A;Wohrer A;Lemaire JJ
通讯作者：
Lemaire JJ
影响因子：
2.9
作者：
Herrmann CS;Rach S;Neuling T;Strüber D
通讯作者：
Strüber D