Gyral window mapping of typical cortical folding using MRI.

Gyral window mapping of typical cortical folding using MRI.
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DOI:
10.2478/s13380-011-0018-1
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发表时间:
2011-06-01
影响因子:
2.1
通讯作者:
Casanova MF
Casanova MF
中科院分区:
医学4区
文献类型:
--
作者:
Dombroski BA;Switala AE;El-Baz AS;Casanova MF

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使用NIH儿科MRI数据库进行规范性发育研究,确定了312名4至23岁的典型发育儿童和年轻成人(168名男性和144名女性)的额叶、颞叶、顶叶和枕叶以及左右半球脑回内的白色物质深度。总体(F1,867 = 0.0002; p = 0.99)或每次访视(F2,867 = 2.18; p = 0.86)的男性和女性组之间无显著年龄差异。脑回窗与年龄有明显的相关性(F1,6544 = 115,p < 0.0001),叶(F3,6544 = 229,p < 0.0001),半球(F1,6544 = 5.23,p = 0.022)、年龄 * 性别(F1,6544 = 13.8,p = 0.0002)、年龄 * 叶(F3,6544 = 120,p = 0.0001)和年龄 * 半球(F1,6544 = 4.41,p = 0.036)。在男性和女性的额叶、颞叶和顶叶中,随着年龄的增长,回旋增加,而在枕叶中观察到相反的效果。本研究中测量的相对脑回深度与脑回化指数显著负相关(p < 0.0001)。先前的研究涉及脑回窗测量短和长皮质皮质预测的差异表达。因此,我们的研究结果表明,皮质连接的模式是可塑性在头二十年的发展。
Using the NIH Pediatric MRI Data Repository for normative developmental studies, white matter depth within the gyri of the frontal, temporal, parietal, and occipital lobes, and of the left and right hemisphere was identified for 312 typically developing children and young adults (168 male and 144 female) between 4 and 23 years of age. There was no significant age difference between male and female groups overall (F1,867 = 0.0002; p = 0.99) or per-visit (F2,867 = 2.18; p = 0.86). There was significant dependence of gyral window upon age (F1,6544 = 115, p < 0.0001), lobe (F3,6544 = 229, p < 0.0001), hemisphere (F1,6544 = 5.23, p = 0.022), age*sex (F1,6544 = 13.8, p = 0.0002), age*lobe (F3,6544 = 120, p = 0.0001), and age*hemisphere (F1,6544 = 4.41, p = 0.036). Gyrification increased with age in both males and females in the frontal, temporal and parietal lobes with opposite effects observed in the occipital lobe. Relative gyral depth, as measured in this study, was significantly (p < 0.0001) inversely correlated with gyrification index. Previous studies relate gyral window measurements to the differential expression of short and long corticocortical projections. Our results therefore suggest that the pattern of corticocortical connections is malleable during the first two decades of development.
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发表时间: 1971-01-01
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