dACC response to presentation of negative feedback predicts stimulant dependence diagnosis and stimulant use severity.
dACC response to presentation of negative feedback predicts stimulant dependence diagnosis and stimulant use severity.
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DOI：
10.1016/j.nicl.2018.05.007
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Shane MS
中科院分区：
文献类型：
--
作者：
Claus ED;Shane MS
兴奋剂依赖个体（SDI）的错误监测异常可能是由于对所犯错误的意识降低，或对这种意识的敏感性降低。这些替代品之间的区别在很大程度上仍然没有区分，但可能具有实质性的临床意义。我们试图更好地表征SDI的错误监控过程的性质和临床相关性，通过比较在呈现负反馈期间仔细隔离的神经反应，a）兴奋剂依赖状态和B）终生使用兴奋剂。48个SDI和23个非SDI进行了一项基于fMRI的时间估计任务，该任务专门设计用于隔离与偶然负反馈的呈现（与期望）相关的神经反应。SDI表现出减少dACC反应相比，非SDI的负反馈的介绍，但只有当错误预期得到控制。此外，终生使用兴奋剂与预期控制的dACC衰减幅度呈负相关。虽然这一发现是最小化后，控制年龄，这些结果表明，SDI的特点可能是一个核心减少神经活动后，错误反馈，在完整的反馈预期的背景下。与终生使用兴奋剂的相关性表明，这种神经衰减可能具有临床意义。检查SDI错误相关的缺陷是否是由于错误意识降低，或对这种意识的敏感性降低。一个时间估计任务，隔离SDI的和非SDI的神经反应的介绍和预期的负反馈。SDI表现出减少dACC反应的负反馈的介绍，但只有当错误预期得到控制。dACC信号改变对呈现负反馈的区分SDI/非SDI，并预测兴奋剂使用史。
Error-monitoring abnormalities in stimulant-dependent individuals (SDIs) may be due to reduced awareness of committed errors, or to reduced sensitivity upon such awareness. The distinction between these alternatives remains largely undifferentiated, but may have substantial clinical relevance. We sought to better characterize the nature, and clinical relevance, of SDIs' error-monitoring processes by comparing carefully isolated neural responses during the presentation of negative feedback to a) stimulant dependence status and b) lifetime stimulant use. Forty-eight SDIs and twenty-three non-SDIs performed an fMRI-based time-estimation task specifically designed to isolate neural responses associated with the presentation (versus expectation) of contingent negative feedback. SDIs showed reduced dACC response compared to non-SDIs following the presentation of negative feedback, but only when error expectancies were controlled. Moreover, lifetime stimulant use correlated negatively with magnitude of expectancy-controlled dACC attenuation. While this finding was minimized after controlling for age, these results suggest that SDIs may be characterized by a core reduction in neural activity following error feedback, in the context of intact feedback expectancies. Correlations with lifetime stimulant use suggest that this neural attenuation may hold clinical significance. Examined whether SDIs error-related deficits are due to reduced error-awareness, or reduced sensitivity upon such awareness. A time-estimation task was used that isolated SDI's and non-SDI's neural responses to the presentation and expectation of negative feedback. SDIs showed reduced dACC response following the presentation of negative feedback, but only when error-expectancies were controlled. dACC signal change to the presentation of negative feedback distinguished SDI/non-SDI, and predicted stimulant use history.
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