Fructose-fed rhesus monkeys: a nonhuman primate model of insulin resistance, metabolic syndrome, and type 2 diabetes.
Fructose-fed rhesus monkeys: a nonhuman primate model of insulin resistance, metabolic syndrome, and type 2 diabetes.
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DOI：
10.1111/j.1752-8062.2011.00298.x
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Havel PJ
中科院分区：
文献类型：
--
作者：
Bremer AA;Stanhope KL;Graham JL;Cummings BP;Wang W;Saville BR;Havel PJ
在过去的几年里，胰岛素抵抗的发生率急剧增加，我们和其他人提出，这种增加可能至少部分归因于饮食中果糖摄入量的增加。然而，饮食诱导的胰岛素抵抗研究的一个主要限制是缺乏相关的动物模型。许多研究，主要是在啮齿动物身上，已经证明高果糖饮食会导致胰岛素抵抗；然而，啮齿动物和灵长类动物之间存在着重要的代谢差异。因此，在灵长类动物身上进行的代谢研究结果对人类生理学的可译性更强，这突显了建立常见代谢条件的非人类灵长类动物模型的重要性。在这份报告中，我们证明了高果糖饮食会在短时间内产生胰岛素抵抗和代谢综合征的许多特征，包括中心性肥胖、血脂异常和炎症；此外，猴子的一部分患上了2型糖尿病。考虑到代谢变化的快速发生，以及对许多人类无法控制的因素的控制能力，在猕猴体内喂食果糖是研究饮食诱导的胰岛素抵抗及其相关并发症的发病机制、预防和治疗的实用而有效的模型系统。
The incidence of insulin resistance has increased dramatically over the past several years, and we and others have proposed that this increase may at least in part be attributable to increased dietary fructose consumption. However, a major limitation to the study of diet-induced insulin resistance is the lack of relevant animal models. Numerous studies, mostly in rodents, have demonstrated that diets high in fructose induce insulin resistance; however, important metabolic differences exist between rodents and primates. Thus, the results of metabolic studies performed in primates are substantively more translatable to human physiology, underscoring the importance of establishing nonhuman primate models of common metabolic conditions. In this report, we demonstrate that a high-fructose diet in rhesus monkeys produces insulin resistance and many features of the metabolic syndrome, including central obesity, dyslipidemia, and inflammation within a short period of time; moreover, a subset of monkeys developed type 2 diabetes. Given the rapidity with which the metabolic changes occur, and the ability to control for many factors that cannot be controlled for in humans, fructose feeding in rhesus monkeys represents a practical and efficient model system in which to investigate the pathogenesis, prevention, and treatment of diet-induced insulin resistance and its related co-morbidities.
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DOI：
10.1161/atvbaha.107.151092
发表时间：
2008-04-01
影响因子：
8.7
作者：
Grundy, Scott M.
通讯作者：
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影响因子：
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影响因子：
2.2
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影响因子：
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通讯作者：
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影响因子：
56.9
作者：
Gibbs, Richard A.;Rogers, Jeffrey;Zwieg, Ann S.
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