Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors?

Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors?
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DOI:
10.1007/s13365-021-01002-x
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发表时间:
2021-08
影响因子:
3.2
通讯作者:
Tamburin S
Tamburin S
中科院分区:
医学4区
文献类型:
--
作者:
Mantovani E;Mariotto S;Gabbiani D;Dorelli G;Bozzetti S;Federico A;Zanzoni S;Girelli D;Crisafulli E;Ferrari S;Tamburin S

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SARS-CoV-2幸存者可能会报告类似肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)的持续症状。我们通过临床、神经精神病学、神经心理学、肺功能评估和血清神经丝轻链(一种轴突损伤生物标志物)探讨了(a) ME/ cfs样症状的患病率和(b)轴突、炎症和/或肺部变化是否可能导致SARS-CoV-2幸存者ME/ cfs样症状。在27%的样本中发现了ME/ cfs样特征。与没有ME/ cfs样症状的组相比,ME/ cfs样症状组在6分钟步行测试中表现出更差的睡眠质量、疲劳、疼痛、抑郁症状、主观认知主诉、Borg基线呼吸困难。这些初步发现引起了人们对SARS-CoV-2幸存者未来可能出现类似ME/ cfs的大流行的担忧。
SARS-CoV-2 survivors may report persistent symptoms that resemble myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We explored (a) ME/CFS-like symptom prevalence and (b) whether axonal, inflammatory, and/or lung changes may contribute to ME/CFS-like symptoms in SARS-CoV-2 survivors through clinical, neuropsychiatric, neuropsychological, lung function assessment, and serum neurofilament light chain, an axonal damage biomarker. ME/CFS-like features were found in 27% of our sample. ME/CFS-like group showed worse sleep quality, fatigue, pain, depressive symptoms, subjective cognitive complaints, Borg baseline dyspnea of the 6-min walking test vs. those without ME/CFS-like symptoms. These preliminary findings raise concern on a possible future ME/CFS-like pandemic in SARS-CoV-2 survivors.
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