Neuromarkers of fatigue and cognitive complaints following chemotherapy for breast cancer: a prospective fMRI investigation.
Neuromarkers of fatigue and cognitive complaints following chemotherapy for breast cancer: a prospective fMRI investigation.
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DOI：
10.1007/s10549-014-3092-6
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发表时间：
2014-09
影响因子：
3.8
通讯作者：
Cimprich, Bernadine
中科院分区：
文献类型：
--
作者：
Askren, Mary K.;Jung, Misook;Berman, Marc G.;Zhang, Min;Therrien, Barbara;Peltier, Scott;Ossher, Lynn;Hayes, Daniel F.;Reuter-Lorenz, Patricia A.;Cimprich, Bernadine
关键词：
目的：应用功能磁共振成像（fMRI）前瞻性研究乳腺癌辅助化疗患者治疗前疲劳和认知功能障碍的预测因素。在接受乳腺癌治疗的妇女中，疲劳和认知功能障碍经常同时发生。我们假设与化疗本身无关的治疗前因素可能会增加治疗后疲劳和认知功能障碍的易感性。接受化疗（n=28）或未接受化疗（n=37）的患者和健康对照（n=32）在化疗前和化疗后一个月进行口头工作记忆任务（VWMT）扫描，并评估疲劳、担忧和认知功能障碍。fMRI活动测量额顶叶执行网络被用于多元线性回归预测治疗后的疲劳和认知功能。化疗组报告了比对照组更大的治疗前疲劳，并表现出神经反应受损，其特征是执行网络活动的空间方差高于非化疗组。此外，化疗组比其他组报告更严重的治疗后疲劳。线性回归表明，治疗前执行网络激活的空间方差预测治疗后的疲劳严重程度和认知投诉，而治疗组、年龄、血红蛋白、焦虑和平均执行网络活动水平对这些结果没有预测作用。与化疗本身相比，治疗前支持注意力和工作记忆的执行网络的神经效率低下（以高空间方差为指标）更能预测治疗后的认知和疲劳症状。这种执行网络妥协可能是治疗前的风险神经标志物，表明患者最有可能从早期干预疲劳和认知功能障碍中受益。
To use functional magnetic resonance imaging (fMRI) to prospectively examine pre-treatment predictors of post-treatment fatigue and cognitive dysfunction in women treated with adjuvant chemotherapy for breast cancer. Fatigue and cognitive dysfunction often co-occur in women treated for breast cancer. We hypothesized that pre-treatment factors, unrelated to chemotherapy per se, might increase vulnerability to post-treatment fatigue and cognitive dysfunction. Patients treated with (n=28) or without chemotherapy (n=37) and healthy controls (n=32) were scanned coincident with pre- and one-month-post-chemotherapy during a verbal working memory task (VWMT) and assessed for fatigue, worry, and cognitive dysfunction. fMRI activity measures in the frontoparietal executive network were used in multiple linear regression to predict post-treatment fatigue and cognitive function. The chemotherapy group reported greater pre-treatment fatigue than controls and showed compromised neural response characterized by higher spatial variance in executive network activity than the non-chemotherapy group. Also, the chemotherapy group reported greater post-treatment fatigue than the other groups. Linear regression indicated that pre-treatment spatial variance in executive network activation predicted post-treatment fatigue severity and cognitive complaints, while treatment group, age, hemoglobin, worry, and mean executive network activity levels did not predict these outcomes. Pre-treatment neural inefficiency (indexed by high spatial variance) in the executive network, which supports attention and working memory, was a better predictor of post-treatment cognitive and fatigue complaints than exposure to chemotherapy per se. This executive network compromise could be a pre-treatment neuromarker of risk, indicating patients most likely to benefit from early intervention for fatigue and cognitive dysfunction.
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影响因子：
45.3
作者：
Deprez, Sabine;Vandenbulcke, Mathieu;Sunaert, Stefan
通讯作者：
Sunaert, Stefan
影响因子：
2.3
作者：
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影响因子：
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通讯作者：
Jonides, John
DOI：
10.1016/j.ijrobp.2010.06.037
发表时间：
2011-11-01
影响因子：
7
作者：
Noal, Sabine;Levy, Christelle;Joly, Florence
通讯作者：
Joly, Florence
DOI：
10.1073/pnas.1334125100
发表时间：
2003-09-16
影响因子：
11.1
作者：
Nelson, JK;Reuter-Lorenz, PA;Smith, EE
通讯作者：
Smith, EE