Symptom-correlated brain regions in young adults with combined-type ADHD: their organization, variability, and relation to behavioral performance.
Symptom-correlated brain regions in young adults with combined-type ADHD: their organization, variability, and relation to behavioral performance.
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DOI：
10.1016/j.pscychresns.2009.11.011
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发表时间：
2010-05-30
影响因子：
2.3
通讯作者：
Banich, Marie T.
中科院分区：
文献类型：
--
作者：
Depue, Brendan E.;Burgess, Gregory C.;Willcutt, Erik G.;Bidwell, L. Cinnamon;Ruzic, Luka;Banich, Marie T.
注意缺陷多动障碍(ADHD)是一种被广泛诊断的儿童精神障碍，可能在成年后继续表现出来。在成人和儿童中，注意力不集中似乎是ADHD最稳定的发育症状。为了确定可能与这些症状有关的神经系统，用功能磁共振成像检查了一组年轻人在面临注意力挑战(Stroop任务)时的大脑激活与注意力不集中症状之间的联系。研究结果表明，与ADHD患者的行为受损有关的脑区有很多，包括执行功能/认知控制(前额叶皮质、背侧纹状体)、奖赏和动机回路(腹侧纹状体)以及刺激表征和时间安排(后脑皮质和小脑)。这也暗示了这些区域对ADHD症状的表现很重要，ADHD组个体间BOLD信号大小的变异性显著高于对照组，ADHD个体的时间序列变异性与症状严重程度和行为表现有关。结果表明，一组不同的大脑结构与ADHD症状有关，这些区域内激活的可变性可能导致注意力控制受损。
Attention Deficit Hyperactivity Disorder (ADHD) is a widely diagnosed psychiatric disorder of childhood that may continue to manifest itself during adulthood. Across adults and children, inattention appears to be the most developmentally stable symptomatology of ADHD. To determine the neural systems that may be linked to such symptoms, the association between brain activation in a group of young adults in the face of an attentional challenge (the Stroop task) and inattentive symptoms was examined with functional magnetic resonance imaging. The results implicated a broad array of brain regions that are linked to behaviors compromised in ADHD, including executive function/cognitive control (prefrontal cortex, dorsal striatum), reward and motivational circuitry (ventral striatum), and stimulus representation and timing (posterior cortex and cerebellum). Also implicating these regions as being important for the manifestation of ADHD symptoms, the variability in the size of the BOLD signal across individuals was significantly higher for the ADHD group than for the control group, and variability across the time series in individuals with ADHD was linked to symptom severity and behavioral performance. The results suggest that a diverse set of brain structures is linked to ADHD symptoms and that the variability of activation within these regions may contribute to compromised attentional control.
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