Association between the melanopsin gene polymorphism OPN4*Ile394Thr and sleep/wake timing in Japanese university students.
Association between the melanopsin gene polymorphism OPN4*Ile394Thr and sleep/wake timing in Japanese university students.
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DOI：
10.1186/1880-6805-33-9
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发表时间：
2014-05-12
影响因子：
3.1
通讯作者：
Higuchi S
中科院分区：
文献类型：
--
作者：
Lee SI;Hida A;Kitamura S;Mishima K;Higuchi S
在我们之前的研究中，我们发现黑视蛋白基因（OPN4）中的Ile394Thr SNP与瞳孔对光反射在功能上相关。这表明 OPN4*Ile394Thr 可能与其他非图像形成反应相关。因此，本研究的目的是确定 OPN4*Ile394Thr 是否与睡眠/唤醒时间相关。共有 348 名健康的日本大学生参与了这项研究。使用头皮毛发对 OPN4 的 Ile394Thr SNP 进行基因分型。工作日和周末的睡眠习惯，包括就寝时间、起床时间和睡眠持续时间分别进行评估。共328份样本进行统计分析，其中TT基因型223份，TC基因型91份，CC基因型14份。三个基因型组之间在年龄或男性/女性分布上没有发现显着差异。基因型组之间的昼夜节律偏好没有显着差异。工作日期间，CC 受试者的就寝时间、醒来时间和睡眠中点时间明显晚于 TT 和 TC 受试者。然而，TT 和 TC 受试者的睡眠习惯没有差异。周末期间，CC受试者的就寝时间显着晚于TT和TC受试者，并且CC受试者的睡眠中点显着晚于TC受试者。我们的研究结果表明 OPN4*Ile394Thr 与睡眠/觉醒时间相关。我们还发现，CC 基因型受试者的睡眠/觉醒时间晚于 TT 或 TC 基因型受试者。
In our previous studies, we found that the Ile394Thr SNP in the melanopsin gene (OPN4) was functionally associated with the pupillary light reflex. This indicates the possibility that OPN4*Ile394Thr is associated with other non-image forming responses. The aim of this study was therefore to determine whether OPN4*Ile394Thr is associated with sleep/wake timing. A total of 348 healthy Japanese university students participated in this study. Scalp hair was used to genotype the Ile394Thr SNP of OPN4. Sleep habits, including bedtime, wake time and sleep duration, were assessed separately for weekdays and weekends. A total of 328 samples, including 223 samples with TT genotype, 91 with TC genotype and 14 with CC genotype, were used for statistical analysis. No significant difference in age or male/female distribution was found among the three genotype groups. There was no significant difference in circadian preference among the genotype groups. During weekdays, bedtime, wake time and midpoint of sleep for CC subjects were significantly later than those for TT and TC subjects. However, there was no difference between TT and TC subjects in any of their sleep habits. During weekends, bedtime of CC subjects was significantly later than those of TT and TC subjects, and the midpoint of sleep of CC subjects was significantly later than that of TC subjects. Our findings demonstrated that OPN4*Ile394Thr is associated with sleep/wake timing. We also found that the sleep/wake timing of subjects with the CC genotype was later than that of subjects with the TT or TC genotype.
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影响因子：
3.1
作者：
Lee SI;Hida A;Tsujimura S;Morita T;Mishima K;Higuchi S
通讯作者：
Higuchi S
影响因子：
2.8
作者：
Aoki, H;Ozeki, Y;Yamada, N
通讯作者：
Yamada, N
DOI：
10.1073/pnas.0808312105
发表时间：
2008-12-16
影响因子：
11.1
作者：
Altimus, C. M.;Guler, A. D.;Hattar, S.
通讯作者：
Hattar, S.
DOI：
10.1002/ajmg.b.30110
发表时间：
2005-02-05
影响因子：
2.8
作者：
Mishima, K;Tozawa, T;Mishima, Y
通讯作者：
Mishima, Y
影响因子：
5.6
作者：
Crowley, Stephanie J.;Acebo, Christine;Carskadon, Mary A.
通讯作者：
Carskadon, Mary A.