The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators.
The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators.
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DOI：
10.1016/j.biocel.2009.07.016
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发表时间：
2010-03
影响因子：
4
通讯作者：
Lefebvre, Veronique
中科院分区：
文献类型：
--
作者：
Lefebvre, Veronique
Sox5、Sox6、Sox13构成性别决定区（sex- determination region, Sry）相关转录因子D组。它们在家族特异性高迁移群（HMG）盒dna结合域和群体特异性卷曲圈域高度保守。后者介导SoxD蛋白二聚化，从而优先结合对DNA识别位点。SoxD基因具有重叠表达和细胞自主控制离散谱系。Sox5和Sox6冗余促进软骨形成，但延缓胶质细胞形成。Sox5阻碍黑素生成，促进神经嵴生成，控制神经发生的速度。Sox6促进红细胞生成，Sox13调节T细胞特异性，是一种自身免疫抗原。SoxD蛋白在软骨细胞中增强Sox9的反转录激活，但在少突胶质细胞和黑素细胞中拮抗Sox9和其他SoxE蛋白，并通过多种机制抑制其他谱系中的转录。虽然SoxD蛋白的生物学和分子功能仍不完全清楚，但已经证明它们在主要谱系中对细胞命运具有关键的调节作用。
Sox5, Sox6, and Sox13 constitute the group D of sex-determining region (Sry)-related transcription factors. They are highly conserved in the family-specific high-mobility-group (HMG) box DNA-binding domain and in a group-specific coiled-coil domain. The latter mediates SoxD protein dimerization and thereby preferential binding to pairs of DNA recognition sites. The SoxD genes have overlapping expression and cell-autonomously control discrete lineages. Sox5 and Sox6 redundantly enhance chondrogenesis, but retard gliogenesis. Sox5 hinders melanogenesis, promotes neural crest generation, and controls the pace of neurogenesis. Sox6 promotes erythropoiesis, and Sox13 modulates T cell specification and is an autoimmune antigen. SoxD proteins enhance transactivation by Sox9 in chondrocytes, but antagonize Sox9 and other SoxE proteins in oligodendrocytes and melanocytes, and also repress transcription through various mechanisms in several other lineages. While their biological and molecular functions remain incompletely understood, the SoxD proteins have thus already proven that they critically modulate cell fate in major lineages.
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