Histological appearance of the synovium in early rheumatoid arthritis.
Histological appearance of the synovium in early rheumatoid arthritis.
复制标题
早期类风湿性关节炎滑膜的组织学外观。
DOI:
10.1016/0049-0172(94)90079-5
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发表时间:
1994
影响因子:
5
通讯作者:
Gall,EP
中科院分区:
文献类型:
--
作者:
SchumacherJr,HR;Bautista,BB;Krauser,RE;Mathur,AK;Gall,EP
This report reviews and discusses studies on the synovial fluid and biopsy specimens of synovial membrane obtained during the first 6 weeks of synovitis that evolved into rheumatoid arthritis (RA). Five previously unreported cases are described. Early changes in the microvasculature and synovial lining seem to antedate the classical chronic inflammation of established RA. Further characterization in the joint tissues in very early RA offers opportunities for identification of exogenous triggers and may allow more appropriate targeting of early therapy to potentially reversible aspects of pathogenesis.
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