Association of TLR9-1237T>C; rs5743836 polymorphism with increased risk of Hodgkin's lymphoma: A case-control study.
Association of TLR9-1237T>C; rs5743836 polymorphism with increased risk of Hodgkin's lymphoma: A case-control study.
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DOI：
10.1371/journal.pone.0272312
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Khader, Yousef
中科院分区：
文献类型：
--
作者：
Al-Khatib, Sohaib;Shabaneh, Amin;Abdo, Nour;Al-Eitan, Laith;Al-Mistarehi, Abdel-Hameed;Khader, Yousef
成熟B细胞肿瘤通常分为霍奇金淋巴瘤和非霍奇金淋巴瘤。霍奇金淋巴瘤的特征是肿瘤性Reed-Sternberg细胞，通常隐藏在炎症背景中，常见的临床表现是纵隔淋巴结病。许多研究将自身免疫与淋巴瘤发生联系起来，这些研究中的很大一部分明显将发病机制追溯到Toll样受体（TLR）对自身衍生核酸的错误检测，特别是细胞内类型的TLR。在这项研究中，我们分析了在约旦阿拉伯人群中，TLR 9（TLR 9 - 1237 T>C; rs 5743836）的一个选定的SNP与HL患者的风险和总生存期之间的关系。本研究共纳入374例受试者; 136例霍奇金淋巴瘤患者和238例匹配的健康对照。从福尔马林固定的石蜡包埋组织中提取基因组DNA。使用测序方案进行遗传多态性的基因分型。结果显示rs 5743836（TLR 9 - 1237 T>C）等位基因在病例群体中的统计学显著更高分布，p值为0.031（<0.05）。在共显性（仅在T/C基因型中具有显著性，p值= 0.030）、显性（p值= 0.025）和超显性（p值= 0.035）模型中研究时，该分布被证明具有显著性。没有模型显示与rs 5743836（TLR 9 - 1237 T>C）SNP相关的存活率的任何统计学显著差异。
Mature B-cell neoplasms are typically divided into Hodgkin and Non-Hodgkin Lymphomas. Hodgkin Lymphoma is characterized by the neoplastic Reed-Sternberg cells, usually harbored in an inflammatory background, with a frequent clinical presentation of mediastinal lymphadenopathy. Many studies link between autoimmunity and lymphomagenesis, a large proportion of these studies evidently trace the pathogenesis back to the misdirected detection of self-derived nucleic acids by Toll-Like Receptors (TLRs), especially those of the intracellular type. In this study, we analyzed the relationship between a selected SNP in TLR9 (TLR9-1237T>C; rs5743836) and the risk and overall survival of HL patients in a Jordanian Arab population. A total of 374 subjects; 136 cases of Hodgkin lymphoma and 238 matched healthy controls were incorporated in this study. Genomic DNA was extracted from formalin-fixed paraffin-embedded tissues. Genotyping of the genetic polymorphisms was conducted using a sequencing protocol. The results show a statistically significant higher distribution of the rs5743836 (TLR9-1237T>C) allele among the case population, with a p-value of 0.031 (<0.05). This distribution proved significant when studied in the codominant (only significant in the T/C genotype, p-value = 0.030), dominant (p-value = 0.025), and overdominant (p-value = 0.035) models. None of the models showed any statistically significant difference in survival associated with the rs5743836 (TLR9-1237T>C) SNP.
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影响因子：
7.3
作者：
Kawasaki T;Kawai T
通讯作者：
Kawai T
影响因子：
2.3
作者：
Miranda-Filho, Adalberto;Pineros, Marion;Bray, Freddie
通讯作者：
Bray, Freddie
影响因子：
8
作者：
通讯作者：
--
DOI：
10.1038/nri1957
发表时间：
2006-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Marshak-Rothstein A
通讯作者：
Marshak-Rothstein A
影响因子：
5
作者：
Carvalho, A.;Cunha, C.;Almeida, A. J.;Osorio, N. S.;Saraiva, M.;Teixeira-Coelho, M.;Pedreiro, S.;Torrado, E.;Domingues, N.;Gomes-Alves, A. G.;Marques, A.;Lacerda, J. F.;da Silva, M. G.;Gomes, M.;Pinto, A. C.;Torres, F.;Rendeiro, P.;Tavares, P.;Di Ianni, M.;Medeiros, R.;Heutink, P.;Bracci, P. M.;Conde, L.;Ludovico, P.;Pedrosa, J.;Maciel, P.;Pitzurra, L.;Aversa, F.;Marques, H.;Paiva, A.;Skibola, C. F.;Romani, L.;Castro, A. G.;Rodrigues, F.
通讯作者：
Rodrigues, F.