Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study.
Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study.
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DOI：
10.1186/1475-2891-8-14
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发表时间：
2009-02-20
影响因子：
5.4
通讯作者：
Heiss G
中科院分区：
文献类型：
--
作者：
Bidulescu A;Chambless LE;Siega-Riz AM;Zeisel SH;Heiss G
风险因素测量的可重复性影响准确确定其与特定结果的关联的能力。胆碱通过甜菜碱依赖途径（单碳代谢）参与同型半胱氨酸甲基化（被认为是心血管疾病的危险因素）到蛋氨酸的过程。目前尚不清楚饮食中胆碱的摄入量是否达到建议的胆碱适当摄入量（男性550毫克/天，女性425毫克/天）。估计平均需求量（EAR）仍有待在人口环境中确定。我们的目的是通过简短的食物频率问卷（FFQ）来确定胆碱和相关营养素（叶酸和蛋氨酸）摄入量的可靠性，并估计双民族人群中胆碱和甜菜碱的膳食摄入量。我们估计了FFQ膳食仪在社区动脉粥样硬化风险（ARIC）研究中的可靠性，以及1990 - 1992年ARIC研究参与者的分层随机样本中胆碱和相关营养素的测量误差（N = 1004）。ARIC在美国四个地区招募了15792名年龄在45-64岁之间的男性和女性（1987-89），对15706名基线研究参与者的饮食进行了评估，使用了Willett 61项FFQ的版本，扩大了一些民族食品。使用混合模型回归估计胆碱、叶酸和蛋氨酸的个体变异。所考虑的营养素的测量误差很大。胆碱的信度系数为0.50（胆碱加甜菜碱的信度系数为0.50），叶酸的信度系数为0.53，蛋氨酸的信度系数为0.48，总能量摄入的信度系数为0.43。在ARIC人群中，饮食胆碱摄入量的中位数和第75百分位数分别为284毫克/天和367毫克/天。94%的男性和89%的女性的胆碱摄入量低于建议的AI标准。非裔美国人的饮食中胆碱摄入量较低，无论男女。报告饮食摄入量的三年可靠性与胆碱和相关营养素相似，在文献中公布的其他微量营养素的范围内。使用简短的FFQ来估计摄入量，ARIC队列中的大多数个体的胆碱摄入量低于建议的AI值。
The repeatability of a risk factor measurement affects the ability to accurately ascertain its association with a specific outcome. Choline is involved in methylation of homocysteine, a putative risk factor for cardiovascular disease, to methionine through a betaine-dependent pathway (one-carbon metabolism). It is unknown whether dietary intake of choline meets the recommended Adequate Intake (AI) proposed for choline (550 mg/day for men and 425 mg/day for women). The Estimated Average Requirement (EAR) remains to be established in population settings. Our objectives were to ascertain the reliability of choline and related nutrients (folate and methionine) intakes assessed with a brief food frequency questionnaire (FFQ) and to estimate dietary intake of choline and betaine in a bi-ethnic population. We estimated the FFQ dietary instrument reliability for the Atherosclerosis Risk in Communities (ARIC) study and the measurement error for choline and related nutrients from a stratified random sample of the ARIC study participants at the second visit, 1990–92 (N = 1,004). In ARIC, a population-based cohort of 15,792 men and women aged 45–64 years (1987–89) recruited at four locales in the U.S., diet was assessed in 15,706 baseline study participants using a version of the Willett 61-item FFQ, expanded to include some ethnic foods. Intraindividual variability for choline, folate and methionine were estimated using mixed models regression. Measurement error was substantial for the nutrients considered. The reliability coefficients were 0.50 for choline (0.50 for choline plus betaine), 0.53 for folate, 0.48 for methionine and 0.43 for total energy intake. In the ARIC population, the median and the 75th percentile of dietary choline intake were 284 mg/day and 367 mg/day, respectively. 94% of men and 89% of women had an intake of choline below that proposed as AI. African Americans had a lower dietary intake of choline in both genders. The three-year reliability of reported dietary intake was similar for choline and related nutrients, in the range as that published in the literature for other micronutrients. Using a brief FFQ to estimate intake, the majority of individuals in the ARIC cohort had an intake of choline below the values proposed as AI.
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影响因子：
4.2
作者：
KIM, YI;MILLER, JW;MASON, JB
通讯作者：
MASON, JB
影响因子：
4.2
作者：
Jacob, RA;Jenden, DJ;Swendseid, ME
通讯作者：
Swendseid, ME
影响因子：
5
作者：
CHAMBLESS, LE;MCMAHON, RP;SHEN, YL
通讯作者：
SHEN, YL
影响因子：
2.1
作者：
Bidulescu, Aurelian;Chambless, Lloyd E;Heiss, Gerardo
通讯作者：
Heiss, Gerardo
影响因子：
4.7
作者：
JAMES, SJ;YIN, L
通讯作者：
YIN, L