The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study.
The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study.
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DOI：
10.1007/s00394-015-0876-3
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发表时间：
2016-03
影响因子：
5
通讯作者：
Mumford SL
中科院分区：
文献类型：
--
作者：
Shimony MK;Schliep KC;Schisterman EF;Ahrens KA;Sjaarda LA;Rotman Y;Perkins NJ;Pollack AZ;Wactawski-Wende J;Mumford SL
前瞻性评估健康育龄妇女中含糖饮料（SSB）、添加糖和总果糖与血清肝酶浓度之间的关系。对259名绝经前妇女（平均年龄27.3±8.2岁，BMI 24.1±kg/m2）进行了长达两个月经周期的前瞻性随访，提供了多达8个空腹血样/周期和4个24小时饮食回顾/周期。有慢性疾病史的妇女被排除在外。测定血清中谷丙转氨酶（ALT）和谷草转氨酶（AST）的含量。线性混合模型估计了平均SSB、添加糖和总果糖摄入量与对数转化肝酶之间的关联，并对年龄、种族、体重指数、总能量和酒精摄入量以及地中海饮食评分进行了调整。SSB摄入量每增加1杯/天，添加糖和总果糖摄入量每增加10克/天，log ALT分别增加0.079 U/L （95% CI 0.022, 0.137）、0.012 U/L （95% CI 0.002, 0.022）和0.031 (0.012,0.050)，log AST分别增加0.029 U/L（0.011, 0.069）、0.007 U/L（0.000, 0.014）和0.017 U/L（0.004, 0.030）。每天摄入≥1.50杯SSB的女性ALT升高0.127 U/L (95% CI 0.001, 0.254)[变化13.5% (95% CI 0.1, 28.9)]， AST升高0.102 (95% CI 0.015, 0.190)[变化10.8% (95% CI 1.5, 20.9)]。在健康的绝经前妇女中，含糖饮料与较高的血清谷丙转氨酶和谷丙转氨酶浓度相关，表明即使是适度的SSB的习惯性消费也可能引起肝脏脂肪生成。
To prospectively assess the association between sugar-sweetened beverages (SSB), added sugar, and total fructose and serum concentrations of liver enzymes among healthy, reproductive-age women. A prospective cohort of 259 premenopausal women (average age 27.3 ± 8.2 years; BMI 24.1 ± kg/m2) were followed up for up to two menstrual cycles, providing up to eight fasting blood specimens/cycle and four 24-h dietary recalls/cycle. Women with a history of chronic disease were excluded. Alanine and aspartate aminotransferases (ALT and AST, respectively) were measured in serum samples. Linear mixed models estimated associations between average SSB, added sugar, and total fructose intake and log-transformed liver enzymes adjusting for age, race, body mass index, total energy and alcohol intake, and Mediterranean diet score. For every 1 cup/day increase in SSB consumption and 10 g/day increase in added sugar and total fructose, log ALT increased by 0.079 U/L (95 % CI 0.022, 0.137), 0.012 U/L (95 % CI 0.002, 0.022), and 0.031 (0.012, 0.050), respectively, and log AST increased by 0.029 U/L (0.011, 0.069), 0.007 U/L (0.000, 0.014), and 0.017 U/L (0.004, 0.030), respectively. Women who consumed ≥ 1.50 cups/day (12 oz can) SSB versus less had 0.127 U/L (95 % CI 0.001, 0.254) higher ALT [percent change 13.5 % (95 % CI 0.1, 28.9)] and 0.102 (95 % CI 0.015, 0.190) higher AST [percent change 10.8 % (95 % CI 1.5, 20.9)]. Sugar-sweetened beverages were associated with higher serum ALT and AST concentrations among healthy premenopausal women, indicating that habitual consumption of even moderate SSB may elicit hepatic lipogenesis.
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影响因子：
4.7
作者：
通讯作者：
--
DOI：
10.1136/bmj.d6891
发表时间：
2011-11-18
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
29.4
作者：
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通讯作者：
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影响因子：
13.5
作者：
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通讯作者：
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