Modes of transmission of influenza B virus in households.
Modes of transmission of influenza B virus in households.
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乙型流感病毒在家庭中的传播方式。
DOI：
10.1371/journal.pone.0108850
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Simmerman JM
中科院分区：
文献类型：
--
作者：
Cowling BJ;Ip DK;Fang VJ;Suntarattiwong P;Olsen SJ;Levy J;Uyeki TM;Leung GM;Peiris JS;Chotpitayasunondh T;Nishiura H;Simmerman JM
虽然甲型和B型流感病毒可通过呼吸道飞沫传播，但小飞沫核“气溶胶”在传播中的重要性仍存在争议。在香港和曼谷，2008-11年，受试者从门诊招募，条件是他们最近发生急性呼吸道疾病，并且他们的家庭接触者都没有生病。在流感快速诊断检测结果呈阳性后，受试者被随机分配到三个以家庭为基础的干预措施之一：手卫生，手卫生加口罩和对照组。对索引病例及其家庭接触者进行了7-10天的随访，以通过呼吸道标本的逆转录聚合酶链反应（RT-PCR）检测来确定继发感染。本分析中纳入了经RT-PCR证实的B型流感指示病例。我们使用一个数学模型来推断传播模式，通过气溶胶传播引起的继发感染的临床表现的明显差异来促进。我们估计，在香港和曼谷的家庭中，分别约有37%和26%的B型流感病毒通过气溶胶传播。在拟合模型中，如果通过气溶胶途径感染，则B型流感病毒感染与56%-72%的发热加咳嗽风险相关，如果通过其他两种传播方式感染，则发热加咳嗽风险为23%-31%。气溶胶传播可能是B型流感病毒传播的一种重要方式。在香港和曼谷，B型流感病毒气溶胶传播的点估计值略低于之前发表的甲型流感病毒估计值。由于该模型固有的多重假设，包括迄今为止支持不同模式B型流感病毒感染的临床特征差异的生物学证据有限，因此在解释这些结果时应谨慎。
While influenza A and B viruses can be transmitted via respiratory droplets, the importance of small droplet nuclei “aerosols” in transmission is controversial. In Hong Kong and Bangkok, in 2008–11, subjects were recruited from outpatient clinics if they had recent onset of acute respiratory illness and none of their household contacts were ill. Following a positive rapid influenza diagnostic test result, subjects were randomly allocated to one of three household-based interventions: hand hygiene, hand hygiene plus face masks, and a control group. Index cases plus their household contacts were followed for 7–10 days to identify secondary infections by reverse transcription polymerase chain reaction (RT-PCR) testing of respiratory specimens. Index cases with RT-PCR-confirmed influenza B were included in the present analyses. We used a mathematical model to make inferences on the modes of transmission, facilitated by apparent differences in clinical presentation of secondary infections resulting from aerosol transmission. We estimated that approximately 37% and 26% of influenza B virus transmission was via the aerosol mode in households in Hong Kong and Bangkok, respectively. In the fitted model, influenza B virus infections were associated with a 56%–72% risk of fever plus cough if infected via aerosol route, and a 23%–31% risk of fever plus cough if infected via the other two modes of transmission. Aerosol transmission may be an important mode of spread of influenza B virus. The point estimates of aerosol transmission were slightly lower for influenza B virus compared to previously published estimates for influenza A virus in both Hong Kong and Bangkok. Caution should be taken in interpreting these findings because of the multiple assumptions inherent in the model, including that there is limited biological evidence to date supporting a difference in the clinical features of influenza B virus infection by different modes.
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DOI：
10.1016/j.jhin.2006.05.022
发表时间：
2006-10
期刊：
The Journal of hospital infection
影响因子：
--
作者：
Tang JW;Li Y;Eames I;Chan PK;Ridgway GL
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Chotipitayasunondh T
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.jhin.2013.04.011
发表时间：
2013-08
期刊：
The Journal of hospital infection
影响因子：
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