Scaffolds for the repair of bone defects in clinical studies: a systematic review.
Scaffolds for the repair of bone defects in clinical studies: a systematic review.
复制标题
临床研究中用于修复骨缺损的支架：系统评价
DOI：
10.1186/s13018-018-0724-2
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发表时间：
2018-02-12
影响因子：
2.6
通讯作者：
Tang ZM
中科院分区：
文献类型：
--
作者：
Zeng JH;Liu SW;Xiong L;Qiu P;Ding LH;Xiong SL;Li JT;Liao XG;Tang ZM
本文就支架材料在骨缺损修复中的应用进行综述。通过PubMed数据库检索相关文献。使用了以下关键词和检索词：“支架”、“患者”、“诊所”、“骨修复”、“骨再生”、“修复骨缺损”、“骨修复”、“骨再生”、“骨过敏症”和“骨再生”。由两名评审员根据纳入和排除标准对文章进行筛选。从PubMed数据库中共检索到373篇文献。筛选后，确定20篇文章与本系统性综述相关。我们收集了生物支架和合成支架的数据。有八个临床研究的生物支架，包括胶原蛋白，明胶，和细胞支架骨愈合。此外，本系统综述还涉及12项人工合成的HA p、TCP、类骨及其复合支架修复骨缺损的临床研究。大量的临床证据表明，支架材料的应用具有良好的促进骨修复和成骨的能力。然而，理想可靠的指南应用不足，该领域的研究数量和质量有待提高。
This systematic review aims to summarize the clinical studies on the use of scaffolds in the repair of bony defects. The relevant articles were searched through PubMed database. The following keywords and search terms were used: “scaffolds,” “patient,” “clinic,” “bone repair,” “bone regeneration,” “repairing bone defect,” “repair of bone,” “osteanagenesis,” “osteanaphysis,” and “osteoanagenesis.” The articles were screened according to inclusion and exclusion criteria, performed by two reviewers. A total of 373 articles were obtained using PubMed database. After screening, 20 articles were identified as relevant for the purpose of this systematic review. We collected the data of biological scaffolds and synthetic scaffolds. There are eight clinical studies of biological scaffolds included collagen, gelatin, and cellular scaffolds for bone healing. In addition, 12 clinical studies of synthetic scaffolds on HAp, TCP, bonelike, and their complex scaffolds for repairing bone defects were involved in this systematic review. There are a lot of clinical evidences showed that application of scaffolds had a good ability to facilitate bone repair and osteogenesis. However, the ideal and reliable guidelines are insufficiently applied and the number and quality of studies in this field remain to be improved.
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DOI：
10.1097/00005373-198409000-00003
发表时间：
1984-01-01
影响因子：
--
作者：
HEPPENSTALL, RB;BRIGHTON, CT;MULLER, G
通讯作者：
MULLER, G
影响因子：
3.1
作者：
Dahl, Morten;Jorgensen, Niklas Rye;Pinholt, Else Marie
通讯作者：
Pinholt, Else Marie
影响因子：
2.8
作者：
Gutierres, M;Hussain, NS;Santos, JD
通讯作者：
Santos, JD
影响因子：
3.1
作者：
Behnia, Hossein;Khojasteh, Arash;Atashi, Amir
通讯作者：
Atashi, Amir
影响因子：
3
作者：
Boden, SD;Kang, J;Heller, JG
通讯作者：
Heller, JG