A hybrid reconstruction algorithm for fluorescence tomography using Kirchhoff approximation and finite element method

A hybrid reconstruction algorithm for fluorescence tomography using Kirchhoff approximation and finite element method
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基尔霍夫近似和有限元法的荧光断层扫描混合重建算法

DOI:
10.1007/s11517-012-0953-1
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发表时间:
2012-12
期刊:
Medical \& biological engineering \& computing
影响因子:
--
通讯作者:
Bai J
Bai J
中科院分区:
其他
文献类型:
--
作者:
Wang X;Cao X;Zhang B;Liu F;Luo J;Bai J

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荧光分子断层成像技术是近年来发展迅速的一种成像技术。然而,它的重建仍然存在挑战,特别是重建精度和计算效率。一般来说,分析方法计算效率高,而数值方法在任意几何形状的重建精度方面具有优势。为了以较低的计算成本获得较高的重建精度,提出了一种基于基尔霍夫近似(KA)的解析方法和基于有限元法(FEM)的数值方法相结合的混合方法。该方法是测试与数值模拟和幻影实验。数值模拟结果表明,与KA方法和FEM方法相比,混合方法在提高重建精度的同时,计算时间减少了40- 70%。仿真实验验证了该方法的可行性。
Fluorescence molecular tomography is a promising imaging modality and has developed fast in the past years. However, challenges remain in its reconstruction, especially for the reconstruction accuracy and computational efficiency. Generally, an analytical method is computationally efficient while a numerical method has advantages in the reconstruction accuracy for arbitrary geometries. To achieve high reconstruction accuracy at low computational cost, a hybrid method that combines an analytical method based on Kirchhoff approximation (KA) and a numerical method based on finite element method (FEM) is proposed. This method is tested with numerical simulations and phantom experiments. Results of numerical simulations indicate that with the hybrid method, the reconstruction accuracy is improved while the computational time decreases by 40–70 % compared with the standalone KA method and FEM. Phantom experiments validate its feasibility for practical applications.
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