Regulatory roles of natural antisense transcripts.
Regulatory roles of natural antisense transcripts.
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DOI:
10.1038/nrm2738
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发表时间:
2009-09
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--
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Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform regulatory RNA group, but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.
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