Clinicopathological and prognostic significance of survivin expression in patients with oral squamous cell carcinoma: evidence from a meta-analysis.
Clinicopathological and prognostic significance of survivin expression in patients with oral squamous cell carcinoma: evidence from a meta-analysis.
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口腔鳞状细胞癌患者生存素表达的临床病理学和预后意义：荟萃分析证据
DOI：
10.1371/journal.pone.0116517
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Cai Z
中科院分区：
文献类型：
--
作者：
Xie S;Xu H;Shan X;Liu B;Wang K;Cai Z
背景Survivin已被认为是口腔鳞状细胞癌（OSCC）的一个有前途的预后标志物，但已发表的关于口腔鳞状细胞癌患者中Survivin表达的数据存在争议。为了解决这个问题，我们进行了一项荟萃分析，系统地评估生存素表达在口腔鳞癌的临床病理和预后意义。方法检索PubMed、Embase、Web of Science和奥维德数据库中关于Survivin表达与口腔鳞癌临床病理及预后的相关性研究。使用汇总比值比（OR）和相应的95%置信区间（CI）来确定生存素的相关性。结果共纳入15篇文献，其中1040例采用免疫组化（IHC）或逆转录聚合酶链反应（RT-PCR）检测Survivin表达。对临床病理变量的Meta分析显示Survivin表达与淋巴结转移（OR = 0.62，95% CI = 0.44-0.88，p < 0.05）和临床分期（OR = 0.63，95% CI = 0.41-0.96，p < 0.05）相关。但Survivin的表达与肿瘤分化程度无关（OR = 0.72，95%CI = 0.26-1.11，p > 0.05），浸润深度（OR = 0.76，95% CI = 0.50-1.14，p > 0.05）、年龄（OR = 0.78，95% CI = 0.48-1.29，p > 0.05）或性别（OR = 1.31，95% CI = 0.86-2.01，p > 0.05）。亚组分析采用分层检测方法显示生存素蛋白的表达和口腔鳞癌的临床病理变量之间没有显着的关联。Survivin蛋白表达与口腔鳞癌患者预后不良相关（HR = 1.62，95% CI = 1.23-2.01，p < 0.05）。结论Survivin是一个潜在的口腔鳞癌预后指标。未来的研究需要更大的样本量和精心设计的纳入标准，以剖析生存素表达在确定口腔鳞癌的临床病理特征和/或预后中的作用。
Background Survivin has been proposed as a promising prognostic marker in oral squamous cell carcinoma (OSCC), but the published data on survivin expression in patients with this condition are controversial. To address this we performed a meta-analysis systematically to assess the clinicopathological and prognostic significance of survivin expression in OSCC. Methods We searched PubMed, Embase, Web of Science and Ovid databases for papers investigating the clinicopathological and prognostic significance of survivin expression in OSCC. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to determine the relevance of survivin. Results A total of 15 papers, including 1040 cases in which survivin expression was detected by immunohistochemistry (IHC) or reverse transcription polymerase chain reaction (RT-PCR), were included. A meta-analysis of clinicopathological variables revealed a correlation between survivin expression and lymph node metastasis (OR = 0.62, 95% CI = 0.44–0.88, p < 0.05) and clinical stage (OR = 0.63, 95% CI = 0.41–0.96, p < 0.05). However, no significant associations were found between survivin expression and tumor differentiation grade (OR = 0.72, 95%CI = 0.26–1.11, p > 0.05), depth of invasion (OR = 0.76, 95% CI = 0.50–1.14, p > 0.05), age (OR = 0.78, 95% CI = 0.48–1.29, p > 0.05) or gender (OR = 1.31, 95% CI = 0.86–2.01, p > 0.05). Subgroup analysis using stratified detection methods showed no significant associations between the expression of survivin protein and clinicopathological variables in OSCC. A correlation between survivin expression and poor prognosis of patients with OSCC (HR = 1.62, 95% CI = 1.23–2.01, p < 0.05) was demonstrated. Conclusion Survivin is a potential prognostic marker of OSCC. Future studies with larger sample sizes and well-designed inclusion criteria will be needed to dissect the role of survivin expression in determining the clinicopathological features and/or prognosis of OSCC.
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