Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations.
Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations.
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微生物生物表面活性剂在化妆品和个人护肤药物配方。
DOI：
10.3390/pharmaceutics12111099
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发表时间：
2020-11-16
期刊：
影响因子：
5.4
通讯作者：
Banat IM
中科院分区：
文献类型：
--
作者：
Adu SA;Naughton PJ;Marchant R;Banat IM
化妆品和个人护理产品在全球范围内使用，通常直接应用于人体皮肤。根据欧洲最近的一项调查，西欧化妆品和个人护理产品的市场价值在2018年达到约840亿欧元，预计到2020年底将增长约6%。由于每年花费在化妆品和个人护理产品上的这些大量资金，沿着化学表面活性剂是它们的许多制剂中的主要成分，其中许多已被报道具有对人类皮肤引起有害影响如过敏反应和皮肤刺激的潜力;因此需要用对皮肤健康具有较少或没有负面影响的其它化合物来代替化学表面活性剂。生物表面活性剂（生物来源的表面活性剂）已经显示出巨大的潜力，例如较低的毒性、皮肤相容性、保护和表面保湿效果，这些是有效护肤程序的关键组分。本文综述了糖脂和脂肽生物表面活性剂的抗菌、皮肤表面保湿和低毒性特性，使其成为目前化妆品和个人护肤药物配方中化学表面活性剂的合适替代品。最后，我们讨论了生物表面活性剂应用的一些挑战和可能的解决方案。
Cosmetic and personal care products are globally used and often applied directly on the human skin. According to a recent survey in Europe, the market value of cosmetic and personal care products in Western Europe reached about 84 billion euros in 2018 and are predicted to increase by approximately 6% by the end of 2020. With these significant sums of money spent annually on cosmetic and personal care products, along with chemical surfactants being the main ingredient in a number of their formulations, of which many have been reported to have the potential to cause detrimental effects such as allergic reactions and skin irritations to the human skin; hence, the need for the replacement of chemical surfactants with other compounds that would have less or no negative effects on skin health. Biosurfactants (surfactants of biological origin) have exhibited great potential such as lower toxicity, skin compatibility, protection and surface moisturizing effects which are key components for an effective skincare routine. This review discusses the antimicrobial, skin surface moisturizing and low toxicity properties of glycolipid and lipopeptide biosurfactants which could make them suitable substitutes for chemical surfactants in current cosmetic and personal skincare pharmaceutical formulations. Finally, we discuss some challenges and possible solutions for biosurfactant applications.
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