Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors.
Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors.
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DOI：
10.1084/jem.193.8.935
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发表时间：
2001-04-16
期刊：
影响因子：
--
通讯作者：
Huang Y
中科院分区：
文献类型：
--
作者：
Zhong G;Fan P;Ji H;Dong F;Huang Y
选择微生物病原体是为了能够逃避或操纵宿主反应，以便在感染后存活。衣原体（Chlamydia）是一种专性胞内病原体，可通过降解宿主主要组织相容性复合体（MHC）抗原表达所需的转录因子，逃避T淋巴细胞的免疫识别。我们现在已经确定了衣原体蛋白酶或蛋白酶体样活性因子（CPAF），分泌到宿主细胞胞质溶胶，这是必要的和足够的宿主转录因子RFX 5和上游刺激因子1（USF-1）的降解。CPAF基因在衣原体菌株中高度保守，但与其他已知基因没有显著的整体同源性。因此，CPAF代表由专性细胞内细菌病原体产生的独特分泌蛋白，以干扰有效的宿主适应性免疫。
Microbial pathogens have been selected for the capacity to evade or manipulate host responses in order to survive after infection. Chlamydia, an obligate intracellular pathogen and the causative agent for many human diseases, can escape T lymphocyte immune recognition by degrading host transcription factors required for major histocompatibility complex (MHC) antigen expression. We have now identified a chlamydial protease– or proteasome–like activity factor (CPAF) that is secreted into the host cell cytosol and that is both necessary and sufficient for the degradation of host transcription factors RFX5 and upstream stimulation factor 1 (USF-1). The CPAF gene is highly conserved among chlamydial strains, but has no significant overall homology with other known genes. Thus, CPAF represents a unique secreted protein produced by an obligate intracellular bacterial pathogen to interfere with effective host adaptive immunity.
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影响因子：
3.2
作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.92.11.4877
发表时间：
1995-05-23
影响因子：
11.1
作者：
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通讯作者：
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