Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment.
Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment.
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DOI：
10.3389/fnagi.2015.00043
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发表时间：
2015
影响因子：
4.8
通讯作者：
Han JS
中科院分区：
文献类型：
--
作者：
Paul S;Jeon WK;Bizon JL;Han JS
大量关于基底前脑胆碱能神经元（BFCN）的研究为它们在应激、认知老化、阿尔茨海默病（AD）和其他神经退行性疾病的病因学中的作用提供了令人信服的证据。BFCN投射到广泛的皮质部位和边缘结构，包括海马，并参与应激和认知。特别是，海马，糖皮质激素应激激素的主要靶组织，与下丘脑-垂体-肾上腺（HPA）轴调节串联的认知功能。本综述总结了糖皮质激素和HPA轴的研究，以努力建立应激影响乙酰胆碱（ACh），糖皮质激素及其受体的释放在认知过程的背景下的方式。我们试图提供糖皮质激素和胆碱能系统之间的分子相互作用的联系，有助于BFCN退化的应激诱导的加速老化和AD的认知能力下降。我们还讨论了动物模型在促进药理学研究中的重要性，这有助于解释疾病状态并提出药理学干预的线索。
A substantial number of studies on basal forebrain (BF) cholinergic neurons (BFCN) have provided compelling evidence for their role in the etiology of stress, cognitive aging, Alzheimer’s disease (AD), and other neurodegenerative diseases. BFCN project to a broad range of cortical sites and limbic structures, including the hippocampus, and are involved in stress and cognition. In particular, the hippocampus, the primary target tissue of the glucocorticoid stress hormones, is associated with cognitive function in tandem with hypothalamic-pituitary-adrenal (HPA) axis modulation. The present review summarizes glucocorticoid and HPA axis research to date in an effort to establish the manner in which stress affects the release of acetylcholine (ACh), glucocorticoids, and their receptor in the context of cognitive processes. We attempt to provide the molecular interactive link between the glucocorticoids and cholinergic system that contributes to BFCN degeneration in stress-induced acceleration of cognitive decline in aging and AD. We also discuss the importance of animal models in facilitating such studies for pharmacological use, to which could help decipher disease states and propose leads for pharmacological intervention.
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影响因子：
16.2
作者：
Conner, JM;Chiba, AA;Tuszynski, MH
通讯作者：
Tuszynski, MH
影响因子：
6.1
作者：
Brayda-Bruno, Laurent;Mons, Nicole;Marighetto, Aline
通讯作者：
Marighetto, Aline
影响因子：
1.9
作者：
BAXTER, MG;BUCCI, DJ;GALLAGHER, M
通讯作者：
GALLAGHER, M
影响因子：
3.9
作者：
Aguilera, Greti
通讯作者：
Aguilera, Greti
影响因子：
3.3
作者：
Coburn-Litvak, PS;Tata, DA;Anderson, BJ
通讯作者：
Anderson, BJ