Oral Administration of Red Ginseng Extract Promotes Neurorestoration after Compressive Spinal Cord Injury in Rats.
Oral Administration of Red Ginseng Extract Promotes Neurorestoration after Compressive Spinal Cord Injury in Rats.
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DOI：
10.1155/2017/1265464
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Sakanaka M
中科院分区：
文献类型：
--
作者：
Zhu P;Samukawa K;Fujita H;Kato H;Sakanaka M
在实验动物中，红参及其活性成分已被证明可以减少脑缺血后的神经元死亡。然而，很少有人知道口服人参提取物对脊髓损伤的影响。采用大鼠脊髓压迫性损伤模型，经口给予红参提取物（RGE）。测量旷场运动评分作为运动功能指标。观察脊髓损伤后的组织学变化和细胞因子的表达。与溶剂处理相比，RGE处理（350 mg/kg/天）显著改善运动评分，达到接近SCI前的水平，防止神经元丢失，并促进SCI后14天脊髓中白色物质的恢复。脊髓损伤后第7天和第14天，RGE治疗组脊髓灰质和白色区Iba-1阳性小胶质细胞聚集减少，VEGF和Bcl-xL表达上调，IL-1β和TNFα表达降低。我们的结论是，口服RGE促进几乎完全的功能恢复与SCI大鼠的运动和行为异常，并防止原位神经元死亡，可能是通过抑制炎症和上调损伤脊髓中的神经保护因子。
Red ginseng and its active ingredients have been shown to decrease neuron death after brain ischemia in experimental animals. However, little is known about the effects of orally administered ginseng extract on spinal cord injury. We orally gave red ginseng extract (RGE) to rats with compressed spinal cord injury (SCI). Open-field locomotor scores were measured as indices of motor function. Histopathological changes and cytokine expressions in situ after SCI were evaluated. Compared to vehicle treatment, RGE treatment (350 mg/kg/day) significantly improved locomotor score up to levels close to those pre-SCI, prevented neuron loss, and facilitated the restoration of white matter in the spinal cord at 14 days after SCI. Treatment with RGE caused less aggregation of Iba-1-positive microglia in grey and white matter at 7 days after SCI, upregulated the expression levels of VEGF and Bcl-xL, and reduced IL-1β and TNFα expressions in the spinal cord at 7 and 14 days after SCI. We concluded that oral administration of RGE facilitates almost complete functional recovery from motor and behavioral abnormalities in rats with SCI and prevents neuron death in situ, possibly through inhibition of inflammation and upregulation of neuroprotective factors in the injured spinal cord.
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