Enterotypes of the human gut mycobiome.
Enterotypes of the human gut mycobiome.
复制标题
DOI：
10.1186/s40168-023-01586-y
复制
发表时间：
2023-08-11
期刊：
影响因子：
15.5
通讯作者：
中科院分区：
文献类型：
--
作者：
人类肠道微生物组的真菌组分，也称为真菌组，在肠道生态和人类健康中起着至关重要的作用。然而，肠道真菌群落的整体结构以及真菌组成的个体间差异在很大程度上仍然未知。在这项研究中，我们收集了来自三大洲16个队列的3363份真菌测序样本，其中包括来自中国的572份新样本。我们使用来自16个队列的3363个样本的ITS分析来鉴定和表征四种真菌菌群肠型。这些肠型在人群和地理位置之间表现出稳定性，并与细菌肠型显著相关。特别地，我们注意到真菌肠型具有强烈的年龄偏好，其中肠型由念珠菌（即，Can_type enterotype）在老年人群中富集，并且赋予与受损的肠屏障相关的多种疾病的增加的风险。此外，双向介导分析显示，与Can_型肠型相关的真菌贡献的有氧呼吸途径可能介导受损的肠屏障与衰老之间的关联。我们表明，人类肠道真菌生物群在个体之间具有稳定的组成模式，并与多种宿主因素（如疾病和宿主年龄）显着相关。视频摘要在线版本包含补充材料，可通过10. 1186/s40168-023-01586-y获取。
The fungal component of the human gut microbiome, also known as the mycobiome, plays a vital role in intestinal ecology and human health. However, the overall structure of the gut mycobiome as well as the inter-individual variations in fungal composition remains largely unknown. In this study, we collected a total of 3363 fungal sequencing samples from 16 cohorts across three continents, including 572 newly profiled samples from China. We identify and characterize four mycobiome enterotypes using ITS profiling of 3363 samples from 16 cohorts. These enterotypes exhibit stability across populations and geographical locations and significant correlation with bacterial enterotypes. Particularly, we notice that fungal enterotypes have a strong age preference, where the enterotype dominated by Candida (i.e., Can_type enterotype) is enriched in the elderly population and confers an increased risk of multiple diseases associated with a compromised intestinal barrier. In addition, bidirectional mediation analysis reveals that the fungi-contributed aerobic respiration pathway associated with the Can_type enterotype might mediate the association between the compromised intestinal barrier and aging. We show that the human gut mycobiome has stable compositional patterns across individuals and significantly correlates with multiple host factors, such as diseases and host age. Video Abstract The online version contains supplementary material available at 10.1186/s40168-023-01586-y.
登录
查看更多内容
影响因子：
5.9
作者：
Badal VD;Vaccariello ED;Murray ER;Yu KE;Knight R;Jeste DV;Nguyen TT
通讯作者：
Nguyen TT
影响因子：
25.7
作者：
Demir M;Lang S;Hartmann P;Duan Y;Martin A;Miyamoto Y;Bondareva M;Zhang X;Wang Y;Kasper P;Bang C;Roderburg C;Tacke F;Steffen HM;Goeser T;Kruglov A;Eckmann L;Stärkel P;Fouts DE;Schnabl B
通讯作者：
Schnabl B
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
4.5
作者：
Di Pierro F
通讯作者：
Di Pierro F