Simulating human cardiac electrophysiology on clinical time-scales.

Simulating human cardiac electrophysiology on clinical time-scales.
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DOI:
10.3389/fphys.2011.00014
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发表时间:
2011
影响因子:
4
通讯作者:
Plank G
Plank G
中科院分区:
医学2区
文献类型:
--
作者:
Niederer S;Mitchell L;Smith N;Plank G

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在这项研究中,在近实时与解剖学上逼真的,生物物理学上详细的人体心脏电生理模型进行计算机实验的可行性证明,使用当前的国家高性能计算设施。通过集成和优化负载平衡和并行I/O来实现所需的性能,从而实现高达16,384个计算核心的可扩展性强的模拟。这种程度的并行化使得人类心脏电生理学的计算机模拟比真实的时间慢240倍,并且可以在大约1分钟内模拟激活时间。这种前所未有的速度满足了将计算机实验引入临床工作流程的要求。
In this study, the feasibility of conducting in silico experiments in near-realtime with anatomically realistic, biophysically detailed models of human cardiac electrophysiology is demonstrated using a current national high-performance computing facility. The required performance is achieved by integrating and optimizing load balancing and parallel I/O, which lead to strongly scalable simulations up to 16,384 compute cores. This degree of parallelization enables computer simulations of human cardiac electrophysiology at 240 times slower than real time and activation times can be simulated in approximately 1 min. This unprecedented speed suffices requirements for introducing in silico experimentation into a clinical workflow.
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