Sex-related differences in depression. Familial evidence.
Sex-related differences in depression. Familial evidence.
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抑郁症的性别相关差异。
DOI：
10.1016/0165-0327(84)90041-7
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发表时间：
1984
影响因子：
6.6
通讯作者：
Klerman,GL
中科院分区：
文献类型：
--
作者：
Rice,J;Reich,T;Andreasen,NC;Lavori,PW;Endicott,J;Clayton,PJ;Keller,MB;Hirschfeld,RM;Klerman,GL
在描述了基于潜在的连续责任分布的家族传播的阈值模型之后，描述了来自NIMH-CRB合作抑郁症心理生物学项目-临床的家庭数据。双相情感障碍没有发现性别差异，而女性亲属与男性亲属相比，原发性单极情感障碍的发病率更高。当根据复发、当前疾病、最近10年内发病和治疗情况对亲属进行分类时，这种影响仍然存在。此外，数据中存在队列效应，表明年轻队列（≥25）的性别比接近1。我们根据父母的情感状况，采用生存分析的方法考察先证者患病兄弟姐妹的比例，考虑疾病从父母传给后代的可能性。发现了母亲效应，母亲对任何性别后代的责任都有更大的影响。这与男性和女性有相同责任的观念不一致，但女性有一个较低的阈值，反映出更多的症状，等等。然而，两性之间的平均倾向性差异可能是由于系统的生物学/文化差异，亲代遗传导致了其平均值的差异。
After a description of threshold models of familial transmission based on an underlying continuous liability distribution, family data from the NIMH-CRB Collaborative Psychobiology of Depression Program-Clinical are described. No sex differences are found for bipolar illness, whereas female relatives have an increased rate of primary unipolar illness when compared to male relatives. This effect persists when relatives are classified according to recurrence, current illness, onset within the last 10 years, and treatment. Moreover, a cohort effect is present in the data and indicates a sex ratio close to one in the young cohort (⩽25).We considered the transmission of illness from parent to offspring by using survival analysis to examine the proportion of ill brothers and sisters of probands according to the affection status of parents. A maternal effect is found, with the mother having a greater influence on the liability of offspring of either sex. This is at odds with the notion that males and females have identical liabilities, but females have a lower threshold reflecting acknowledgment of more symptoms, etc. However, the mean difference in liability between the sexes may be due to systematic biological/cultural differences, with parental transmission contributing to variation about their means.
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爱荷华 500：躁狂症和抑郁症患者亲属的情感障碍。
DOI：
10.1176/ajp.139.2.209
发表时间：
1982
期刊：
The American journal of psychiatry
影响因子：
--
作者：
G. Winokur;M. Tsuang;R. Crowe
通讯作者：
R. Crowe
影响因子：
10.5
作者：
R. Cadoret;G. Winokur;P. Clayton
通讯作者：
P. Clayton
不同发病年龄的疾病的遗传倾向，特别是糖尿病
影响因子：
1.9
作者：
D. Falconer
通讯作者：
D. Falconer
情感障碍患者亲属中重度抑郁症发病率的出生队列趋势。
影响因子：
--
作者：
Klerman,GL;Lavori,PW;Rice,J;Reich,T;Endicott,J;Andreasen,NC;Keller,MB;Hirschfield,RM
通讯作者：
Hirschfield,RM
影响因子：
--
作者：
M. Weissman;K. Kidd;B. Prusoff
通讯作者：
M. Weissman;K. Kidd;B. Prusoff