Distance metrics for ranked evolutionary trees.
Distance metrics for ranked evolutionary trees.
复制标题
排名进化树的距离指标。
DOI:
10.1073/pnas.1922851117
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发表时间:
2020-11-17
影响因子:
11.1
通讯作者:
Palacios JA
中科院分区:
文献类型:
--
作者:
Kim J;Rosenberg NA;Palacios JA
Rooted binary trees inferred from molecular sequence data provide information about the evolutionary history of populations and species. We introduce metrics on ranked tree shapes and ranked genealogies, in which the shape and temporal branching order in a tree are considered, but not the taxon labels. Our metrics enable quantification of evolutionary differences, assessment of tree uncertainty, and construction of statistical summaries of a tree distribution. They are computationally efficient and particularly useful for comparing phylodynamics of infectious diseases involving heterochronous samples and for comparative analyses of organisms that live in different geographic regions. Genealogical tree modeling is essential for estimating evolutionary parameters in population genetics and phylogenetics. Recent mathematical results concerning ranked genealogies without leaf labels unlock opportunities in the analysis of evolutionary trees. In particular, comparisons between ranked genealogies facilitate the study of evolutionary processes of different organisms sampled at multiple time periods. We propose metrics on ranked tree shapes and ranked genealogies for lineages isochronously and heterochronously sampled. Our proposed tree metrics make it possible to conduct statistical analyses of ranked tree shapes and timed ranked tree shapes or ranked genealogies. Such analyses allow us to assess differences in tree distributions, quantify estimation uncertainty, and summarize tree distributions. We show the utility of our metrics via simulations and an application in infectious diseases.
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影响因子:
1.4
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通讯作者:
Holmes, S
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作者:
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