Fronto-temporal dysfunction in appetitive regulation of bulimia nervosa with affective disorders: A regional homogeneity and remote connectivity pattern analysis.
Fronto-temporal dysfunction in appetitive regulation of bulimia nervosa with affective disorders: A regional homogeneity and remote connectivity pattern analysis.
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神经性贪食症伴情感障碍的食欲调节中的额颞叶功能障碍：区域同质性和远程连接模式分析。
DOI：
10.1016/j.jad.2023.08.036
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发表时间：
2023
影响因子：
6.6
通讯作者：
Zhenchang Wang
中科院分区：
文献类型：
--
作者：
Jiani Wang;Lirong Tang;Miao Wang;Guo;Weihua Li;Yiling Wang;Xuemei Wang;Hao Wang;Zhenghan Yang;Zhanjiang Li;Qian Chen;Peng Zhang;Zhenchang Wang
本研究的目的是评估BN患者的情感性精神障碍及其与适应不良饮食behaviors.MethodsA共42 BN患者的情感性精神障碍（焦虑和抑郁）和47名健康对照（HC）的脑功能改变在这项研究中。静息状态的功能磁共振成像数据进行了分析的功能变化所示的区域同质性的基础上肯德尔的一致性系数（KCC-ReHo）和种子为基础的功能连接（FC）。一个主成分分析（PCA）模型被用来确定BN group.ResultsPatients在BN组的行为问卷内的共性表现出减少ReHo在双边额中回（MFG）和右缘上回（SMG）。此外，BN组显示左侧MFG与右侧颞下回（ITG）之间的FC增加;右侧MFG与双侧颞叶和左侧颞中回（MTG）之间的FC减少;右侧SMG与左侧上级颞回（STG）和右侧额下回（IFG）之间的FC减少。在FC-行为关联分析中，第二主成分（PC 2）与FC之间的左MFG和右ITG.ConclusionBased上的脑功能分析（ReHo和FC），这项研究揭示了显着的异常变化，在BN患者的额颞区的情感障碍。这些区域，作为额颞叶电路，与克制和情绪化进食行为有关。我们的发现为这种疾病的神经机制提供了新的线索。
ObjectiveThe aim of this study was to assess brain functional alterations in BN patients with affective disorders and their association with maladaptive eating behaviors.MethodsA total of 42 BN patients with affective disorders (anxiety and depression) and 47 healthy controls (HCs) were enrolled in this study. The resting-state fMRI data were analyzed for functional changes as indicated by regional homogeneity based on Kendall's coefficient of concordance (KCC-ReHo) and seed-based functional connectivity (FC). A principal component analysis (PCA) model was used to identify the commonalities within the behavioral questionnaires from the BN group.ResultsPatients in the BN group showed decreased ReHo in the bilateral middle frontal gyrus (MFG) and right supramarginal gyrus (SMG). Additionally, the BN group showed increased FC between the left MFG and the right inferior temporal gyrus (ITG); decreased FC between the right MFG and the bilateral insula and the left middle temporal gyrus (MTG); and decreased FC between the right SMG and the left superior temporal gyrus (STG) and right inferior frontal gyrus (IFG). In the FC-behavior association analysis, the second principal component (PC2) was negatively correlated with FC between the left MFG and the right ITG.ConclusionBased on a brain functional analysis (ReHo and FC), this study revealed significant aberrant changes in the frontal-temporal regions of BN patients with affective disorders. These regions, which serve as fronto-temporal circuitry, are associated with restraint and emotional eating behaviors. Our findings shed new light on the neural mechanisms underlying the condition.
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DOI：
10.1176/appi.ajp.2011.11010094
发表时间：
2011-11
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Marsh R;Horga G;Wang Z;Wang P;Klahr KW;Berner LA;Walsh BT;Peterson BS
通讯作者：
Peterson BS
影响因子：
5.7
作者：
Oakes, Terrence R.;Fox, Andrew S.;Davidson, Richard J.
通讯作者：
Davidson, Richard J.
影响因子：
16.4
作者：
Berridge, Kent C.;Robinson, Terry E.
通讯作者：
Robinson, Terry E.
影响因子：
5.7
作者：
Berthoud HR
通讯作者：
Berthoud HR
影响因子：
5.5
作者：
Tanofsky-Kraff, Marian;Theim, Kelly R.;Yanovski, Jack A.
通讯作者：
Yanovski, Jack A.