Metabolic and hedonic drives in the neural control of appetite: who is the boss?
Metabolic and hedonic drives in the neural control of appetite: who is the boss?
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DOI：
10.1016/j.conb.2011.09.004
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发表时间：
2011-12
影响因子：
5.7
通讯作者：
Berthoud HR
中科院分区：
文献类型：
--
作者：
Berthoud HR
肥胖症在所有发达国家都在上升，这种流行病的很大一部分归因于由一直存在的食物线索引起的过量热量摄入，以及在充足的环境中容易获得能量密集的食物。显然，有强大的自我平衡调节机制，使许多暴露于这种环境的个体的体重在其成年生活中保持非常稳定。然而，另一些人似乎吃东西不仅是因为新陈代谢的需要，而且是因为过度的享乐驱动，使他们感觉更好，缓解压力。在极端情况下，一些人表现出对食物的成瘾行为，并与药物和酒精成瘾相类似。然而，与毒品和酒精不同，食物是日常必需品。最近在识别代表饮食的代谢和享乐驱动之间界面的神经回路方面取得了相当大的进展。我们将首先关注代谢信号调节皮质边缘系统（自下而上）中认知和奖励功能处理的能力，然后关注认知和情绪大脑可能超越稳态调节（自上而下）的途径，从而涵盖这些新发现。
Obesity is on the rise in all developed countries, and a large part of this epidemic has been attributed to excess caloric intake induced by ever present food cues and the easy availability of energy dense foods in an environment of plenty. Clearly, there are strong homeostatic regulatory mechanisms keeping body weight of many individuals exposed to this environment remarkably stable over their adult life. Other individuals, however, seem to eat not only because of metabolic need, but also because of excessive hedonic drive to make them feel better and relief stress. In the extreme, some individuals exhibit addiction-like behavior towards food, and parallels have been drawn to to drug and alcohol addiction. However, there is an important distinction in that unlike drugs and alcohol, food is a daily necessity. Considerable advances have been made recently in the identification of neural circuits that represent the interface between the metabolic and hedonic drives of eating. We will cover these new findings by focusing first on the capacity of metabolic signals to modulate processing of cognitive and reward functions in cortico-limbic systems (bottom-up) and then on pathways by which the cognitive and emotional brain may override homeostatic regulation (top-down).
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DOI：
10.1017/s1355617710000354
发表时间：
2010-07-01
影响因子：
2.6
作者：
Brogan, Amy;Hevey, David;Pignatti, Riccardo
通讯作者：
Pignatti, Riccardo
影响因子：
2.9
作者：
Getchell, Thomas V.;Kwong, Kevin;Getchell, Marilyn L.
通讯作者：
Getchell, Marilyn L.
影响因子：
4.8
作者：
Baird, John-Paul;Choe, Angela;Grigg, Lindsay A.
通讯作者：
Grigg, Lindsay A.
影响因子：
56.9
作者：
DeFalco, J;Tomishima, M;Friedman, JM
通讯作者：
Friedman, JM
DOI：
10.1038/ijo.2010.84
发表时间：
2010-10
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Bruce AS;Holsen LM;Chambers RJ;Martin LE;Brooks WM;Zarcone JR;Butler MG;Savage CR
通讯作者：
Savage CR