Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications.
Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications.
复制标题
控制能量平衡和压力调节的神经内分泌回路:功能重叠和治疗意义。
DOI:
10.1016/j.cmet.2014.01.020
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发表时间:
2014-06-03
期刊:
影响因子:
29
通讯作者:
Ryan KK
中科院分区:
文献类型:
--
作者:
Ulrich-Lai YM;Ryan KK
Significant co-morbidities between obesity-related metabolic disease and stress-related psychological disorders suggest important functional interactions between energy balance and brain stress integration. Largely overlapping neural circuits control these systems, and this anatomical arrangement optimizes opportunities for mutual influence. Here we first review the current literature identifying effects of metabolic neuroendocrine signals on stress regulation, and vice versa. Next, the contributions of reward driven food intake to these metabolic and stress interactions are discussed. Lastly, we consider the inter-relationships among metabolism, stress and reward in light of their important implications in the development of therapies for metabolism- or stress-related disease.
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