Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications.

Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications.
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控制能量平衡和压力调节的神经内分泌回路:功能重叠和治疗意义。

DOI:
10.1016/j.cmet.2014.01.020
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发表时间:
2014-06-03
期刊:
影响因子:
29
通讯作者:
Ryan KK
Ryan KK
中科院分区:
生物学1区
文献类型:
--
作者:
Ulrich-Lai YM;Ryan KK

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肥胖相关的代谢性疾病和压力相关的心理障碍之间的显着共病性表明能量平衡和大脑压力整合之间的重要功能相互作用。神经回路大部分重叠,控制着这些系统,这种解剖学上的安排优化了相互影响的机会。在这里,我们首先回顾了目前的文献,确定代谢神经内分泌信号对应激调节的影响,反之亦然。接下来,奖励驱动的食物摄入这些代谢和压力的相互作用的贡献进行了讨论。最后,我们考虑代谢,压力和奖励之间的相互关系,在他们的重要意义,在发展的治疗代谢或压力相关的疾病。
Significant co-morbidities between obesity-related metabolic disease and stress-related psychological disorders suggest important functional interactions between energy balance and brain stress integration. Largely overlapping neural circuits control these systems, and this anatomical arrangement optimizes opportunities for mutual influence. Here we first review the current literature identifying effects of metabolic neuroendocrine signals on stress regulation, and vice versa. Next, the contributions of reward driven food intake to these metabolic and stress interactions are discussed. Lastly, we consider the inter-relationships among metabolism, stress and reward in light of their important implications in the development of therapies for metabolism- or stress-related disease.
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