Temporal Reliability and Lateralization of the Resting-State Language Network
Temporal Reliability and Lateralization of the Resting-State Language Network
复制标题
静息态语言网络的时间可靠性和偏侧化
DOI：
10.1371/journal.pone.0085880
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发表时间：
2014-01
期刊：
影响因子：
3.7
通讯作者：
Niu, Zhendong
中科院分区：
文献类型：
--
作者：
Zou, Qihong;Wang, Jue;Gao, Jia-Hong;Niu, Zhendong
语言的神经处理回路很复杂，但与布洛卡区和韦尼克区高度相关。这两个区域的左侧优势是最早观察到的大脑不对称。结果表明，静息状态下的语言网络及其功能不对称性在不同机构中具有可重复性。然而，关于静息状态语言网络的时间可靠性及其功能不对称性的研究还很缺乏。在本研究中，我们建立了基于种子的语言网络静息状态功能连通性分析，种子区域位于Broca's和Wernicke's区域，并研究了语言网络的时间可靠性及其功能不对称性。语言网络被发现在短期和长期都是暂时可靠的。在功能不对称方面，Broca区以左侧偏侧为主，Wernicke区以右侧偏侧为主。这两个区域的功能不对称也显示出较高的短期和长期可靠性。此外，我们还研究了全局信号回归（GSR）对静息状态语言网络可靠性的影响，结果表明GSR对静息状态语言网络的时间可靠性的影响可以忽略不计。本研究为静息状态语言网络的跨文化和临床研究提供了方法学基础，并因其可靠性高，建议优先采用基于种子的功能连接。
The neural processing loop of language is complex but highly associated with Broca's and Wernicke's areas. The left dominance of these two areas was the earliest observation of brain asymmetry. It was demonstrated that the language network and its functional asymmetry during resting state were reproducible across institutions. However, the temporal reliability of resting-state language network and its functional asymmetry are still short of knowledge. In this study, we established a seed-based resting-state functional connectivity analysis of language network with seed regions located at Broca's and Wernicke's areas, and investigated temporal reliability of language network and its functional asymmetry. The language network was found to be temporally reliable in both short- and long-term. In the aspect of functional asymmetry, the Broca's area was found to be left lateralized, while the Wernicke's area is mainly right lateralized. Functional asymmetry of these two areas revealed high short- and long-term reliability as well. In addition, the impact of global signal regression (GSR) on reliability of the resting-state language network was investigated, and our results demonstrated that GSR had negligible effect on the temporal reliability of the resting-state language network. Our study provided methodology basis for future cross-culture and clinical researches of resting-state language network and suggested priority of adopting seed-based functional connectivity for its high reliability.
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影响因子：
5.7
作者：
Van Essen, DC
通讯作者：
Van Essen, DC
影响因子：
5.7
作者：
Kuo, WJ;Yeh, TC;Hsieh, JC
通讯作者：
Hsieh, JC
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3.7
作者：
Song XW;Dong ZY;Long XY;Li SF;Zuo XN;Zhu CZ;He Y;Yan CG;Zang YF
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Zang YF
影响因子：
5.7
作者：
Constable, R. Todd;Vohr, Betty R.;Scheinost, Dustin;Benjamin, Jennifer R.;Fulbright, Robert K.;Lacadie, Cheryl;Schneider, Karen C.;Katz, Karol H.;Zhang, Heping;Papademetris, Xenophon;Ment, Laura R.
通讯作者：
Ment, Laura R.
影响因子：
5.7
作者：
Tomasi, D;Caparelli, EC;Ernst, T
通讯作者：
Ernst, T