Exposure of Mice to Thirdhand Smoke Modulates In Vitro and In Vivo Platelet Responses.
Exposure of Mice to Thirdhand Smoke Modulates In Vitro and In Vivo Platelet Responses.
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DOI：
10.3390/ijms23105595
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发表时间：
2022-05-17
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
吸烟是多种有害疾病的危险因素，如癌症、呼吸系统疾病和心血管疾病。血栓形成是几种心血管疾病状态的一个重要和常见方面，其风险已知会因首次吸烟和二手吸烟而增加。最近，吸烟后残留的香烟烟雾（被称为三手烟或THS）受到了越来越多的关注，因为有证据表明它也会对健康产生负面影响。事实上，我们之前已经表明，暴露于三手烟6个月会增加血栓形成的风险。然而，既没有研究hs诱导血栓形成的时间依赖性，也没有研究其性别依赖性。因此，在本研究中，我们在较短时间（具体为3个月）暴露于三手烟的雄性和雌性小鼠中调查了这些问题。我们发现，暴露于3个月的小鼠的血小板在激动剂的作用下表现出增强的激活。此外，我们还表明，暴露于三手烟的雌雄小鼠尾部出血减少，血栓闭塞时间缩短。就性别的作用而言，有趣的是，观察到在血栓发展和止血以及血小板聚集方面的两性差异。总之，我们的研究结果表明，将小鼠暴露于三手烟3个月足以使它们容易形成血栓；这似乎是由血小板活动增加引起的，至少部分是由血小板活动增加引起的，而且在两性中表现得并不相同。
Smoking is a risk factor for a variety of deleterious conditions, such as cancer, respiratory disease and cardiovascular disease. Thrombosis is an important and common aspect of several cardiovascular disease states, whose risk is known to be increased by both first- and secondhand smoke. More recently, the residual cigarette smoke that persists after someone has smoked (referred to as thirdhand smoke or THS) has been gaining more attention, since it has been shown that it also negatively affects health. Indeed, we have previously shown that 6-month exposure to THS increases the risk of thrombogenesis. However, neither the time-dependence of THS-induced thrombus formation, nor its sex dependence have been investigated. Thus, in the present study, we investigated these issues in the context of a shorter exposure to THS, specifically 3 months, in male and female mice. We show that the platelets from 3-month THS-exposed mice exhibited enhanced activation by agonists. Moreover, we also show that mice of both sexes exposed to THS have decreased tail bleeding as well as decreased thrombus occlusion time. In terms of the role of sex, intersex disparities in thrombus development and hemostasis as well as in platelet aggregation were, interestingly, observed. Together, our findings show that exposing mice to THS for 3 months is sufficient to predispose them to thrombosis; which seems to be driven, at least in part, by an increased activity in platelets, and that it does not manifest equally in both sexes.
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DOI：
10.1016/0735-1097(93)90773-t
发表时间：
1993-12-01
影响因子：
24
作者：
KOOL, MJF;HOEKS, APG;VANBORTEL, LMAB
通讯作者：
VANBORTEL, LMAB
DOI：
10.1158/1055-9965.epi-09-0874
发表时间：
2009-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Goniewicz ML;Havel CM;Peng MW;Jacob P 3rd;Dempsey D;Yu L;Zielinska-Danch W;Koszowski B;Czogala J;Sobczak A;Benowitz NL
通讯作者：
Benowitz NL
DOI：
10.3390/ijerph110100202
发表时间：
2014-01-01
影响因子：
--
作者：
Caruso, Rosalie V.;O'Connor, Richard J.;Fong, Geoffrey T.
通讯作者：
Fong, Geoffrey T.
影响因子：
4.1
作者：
Jacob P 3rd;Benowitz NL;Destaillats H;Gundel L;Hang B;Martins-Green M;Matt GE;Quintana PJ;Samet JM;Schick SF;Talbot P;Aquilina NJ;Hovell MF;Mao JH;Whitehead TP
通讯作者：
Whitehead TP
影响因子：
3.7
作者：
Martins-Green M;Adhami N;Frankos M;Valdez M;Goodwin B;Lyubovitsky J;Dhall S;Garcia M;Egiebor I;Martinez B;Green HW;Havel C;Yu L;Liles S;Matt G;Destaillats H;Sleiman M;Gundel LA;Benowitz N;Jacob P 3rd;Hovell M;Winickoff JP;Curras-Collazo M
通讯作者：
Curras-Collazo M