Assessments of function and biochemistry of the anterior cingulate cortex in schizophrenia.
Assessments of function and biochemistry of the anterior cingulate cortex in schizophrenia.
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DOI：
10.1016/j.biopsych.2010.04.013
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发表时间：
2010-10-01
影响因子：
10.6
通讯作者：
Lahti, Adrienne C.
中科院分区：
文献类型：
--
作者：
Reid, Meredith A.;Stoeckel, Luke E.;White, David M.;Avsar, Kathy B.;Bolding, Mark S.;Akella, N. Shastry;Knowlton, Robert C.;den Hollander, Jan A.;Lahti, Adrienne C.
关键词：
神经影像学和电生理学研究一直提供证据表明，精神分裂症患者的前扣带皮层（ACC）/内侧额叶皮层（MFC）功能受损。在这项研究中，我们试图澄清这种异常的性质相结合的质子磁共振波谱（1H-MRS）与功能磁共振成像（fMRI）在3 T。我们使用单体素MRS在背侧ACC和功能磁共振成像过程中获得的Stroop颜色命名任务的性能进行调查的神经化学和功能反应的ACC/MFC在26个稳定的，药物治疗，精神分裂症和23个匹配的健康对照组。在精神分裂症受试者中，我们发现内侧额叶壁的血氧水平依赖性（BOLD）信号降低，与健康受试者相比，显着的集群仅限于更多的背部区域。此外，我们观察到的N-乙酰天冬氨酸/肌酸（NAA/Cr）水平的趋势水平下降，并在精神分裂症受试者的NAA/Cr水平和BOLD信号之间的显着正相关，不存在于健康受试者。此外，在这组用药受试者中，我们没有发现谷氨酸+谷氨酰胺（Glx）/Cr水平降低的证据，但Glx/Cr水平与阴性症状之间存在显著负相关。我们的研究结果表明，异常的NAA水平，这可能反映了精神分裂症相关的神经元功能障碍，影响神经元的生理，减少BOLD反应证明。
Neuroimaging and electrophysiological studies have consistently provided evidence of impairment in anterior cingulate cortex (ACC)/medial frontal cortex (MFC) function in people with schizophrenia. In this study, we sought to clarify the nature of this abnormality by combining proton magnetic resonance spectroscopy (1H-MRS) with functional magnetic resonance imaging (fMRI) at 3T. We used single-voxel MRS acquired in the dorsal ACC and fMRI during performance of a Stroop color-naming task to investigate the neurochemistry and functional response of the ACC/MFC in 26 stable, medicated, subjects with schizophrenia and 23 matched healthy controls. In schizophrenia subjects, we found decreased blood oxygen level-dependent (BOLD) signal in the medial frontal wall, with significant clusters restricted to more dorsal regions compared to healthy subjects. In addition, we observed a trend level decrease in N-acetylaspartate/creatine (NAA/Cr) levels, and a significant positive correlation between NAA/Cr level and the BOLD signal in schizophrenia subjects that did not exist in healthy subjects. Furthermore, in this group of medicated subjects, we did not find evidence of decreased glutamate + glutamine (Glx)/Cr levels, but there was a significant negative correlation between Glx/Cr levels and negative symptoms. Our results suggest that abnormal NAA levels, which may reflect a neuronal dysfunction related to schizophrenia, affect neuronal physiology, as evidenced by reduced BOLD response.
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